Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation

Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation.

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Autores principales:	Violet R. Mukaro, Alex Quach, Michelle E. Gahan, Bernadette Boog, Zhi H. Huang, Xiuhui Gao, Carol Haddad, Suresh Mahalingam, Charles S. Hii, Antonio Ferrante
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d8d32e467ee4dd0a9417a3616257e88
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spelling	oai:doaj.org-article:6d8d32e467ee4dd0a9417a3616257e882021-12-02T14:39:04ZSmall tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation10.1038/s41467-018-03640-y2041-1723https://doaj.org/article/6d8d32e467ee4dd0a9417a3616257e882018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03640-yhttps://doaj.org/toc/2041-1723Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation.Violet R. MukaroAlex QuachMichelle E. GahanBernadette BoogZhi H. HuangXiuhui GaoCarol HaddadSuresh MahalingamCharles S. HiiAntonio FerranteNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Violet R. Mukaro Alex Quach Michelle E. Gahan Bernadette Boog Zhi H. Huang Xiuhui Gao Carol Haddad Suresh Mahalingam Charles S. Hii Antonio Ferrante Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
description	Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation.
format	article
author	Violet R. Mukaro Alex Quach Michelle E. Gahan Bernadette Boog Zhi H. Huang Xiuhui Gao Carol Haddad Suresh Mahalingam Charles S. Hii Antonio Ferrante
author_facet	Violet R. Mukaro Alex Quach Michelle E. Gahan Bernadette Boog Zhi H. Huang Xiuhui Gao Carol Haddad Suresh Mahalingam Charles S. Hii Antonio Ferrante
author_sort	Violet R. Mukaro
title	Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_short	Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_full	Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_fullStr	Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_full_unstemmed	Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_sort	small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6d8d32e467ee4dd0a9417a3616257e88
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Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation

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