Malaria hotspots explained from the perspective of ecological theory underlying insect foraging

Abstract Hotspots constitute the major reservoir for residual malaria transmission, with higher malaria incidence than neighbouring areas, and therefore, have the potential to form the cornerstone for successful intervention strategies. Detection of malaria hotspots is hampered by their heterogenous...

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Autores principales:	Yared Debebe, Sharon Rose Hill, Habte Tekie, Sisay Dugassa, Richard J. Hopkins, Rickard Ignell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d8e700c6e2d4f4f87d6bc5658a74b56
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spelling	oai:doaj.org-article:6d8e700c6e2d4f4f87d6bc5658a74b562021-12-02T11:43:43ZMalaria hotspots explained from the perspective of ecological theory underlying insect foraging10.1038/s41598-020-78021-x2045-2322https://doaj.org/article/6d8e700c6e2d4f4f87d6bc5658a74b562020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78021-xhttps://doaj.org/toc/2045-2322Abstract Hotspots constitute the major reservoir for residual malaria transmission, with higher malaria incidence than neighbouring areas, and therefore, have the potential to form the cornerstone for successful intervention strategies. Detection of malaria hotspots is hampered by their heterogenous spatial distribution, and the laborious nature and low sensitivity of the current methods used to assess transmission intensity. We adopt ecological theory underlying foraging in herbivorous insects to vector mosquito host seeking and modelling of fine-scale landscape features at the village level. The overall effect of environmental variables on the density of indoor mosquitoes, sporozoite infected mosquitoes, and malaria incidence, was determined using generalized linear models. Spatial analyses were used to identify hotspots for malaria incidence, as well as malaria vector density and associated sporozoite prevalence. We identify household occupancy and location as the main predictors of vector density, entomological inoculation rate and malaria incidence. We propose that the use of conventional vector control and malaria interventions, integrated with their intensified application targeting predicted hotspots, can be used to reduce malaria incidence in endemic and residual malaria settings.Yared DebebeSharon Rose HillHabte TekieSisay DugassaRichard J. HopkinsRickard IgnellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yared Debebe Sharon Rose Hill Habte Tekie Sisay Dugassa Richard J. Hopkins Rickard Ignell Malaria hotspots explained from the perspective of ecological theory underlying insect foraging
description	Abstract Hotspots constitute the major reservoir for residual malaria transmission, with higher malaria incidence than neighbouring areas, and therefore, have the potential to form the cornerstone for successful intervention strategies. Detection of malaria hotspots is hampered by their heterogenous spatial distribution, and the laborious nature and low sensitivity of the current methods used to assess transmission intensity. We adopt ecological theory underlying foraging in herbivorous insects to vector mosquito host seeking and modelling of fine-scale landscape features at the village level. The overall effect of environmental variables on the density of indoor mosquitoes, sporozoite infected mosquitoes, and malaria incidence, was determined using generalized linear models. Spatial analyses were used to identify hotspots for malaria incidence, as well as malaria vector density and associated sporozoite prevalence. We identify household occupancy and location as the main predictors of vector density, entomological inoculation rate and malaria incidence. We propose that the use of conventional vector control and malaria interventions, integrated with their intensified application targeting predicted hotspots, can be used to reduce malaria incidence in endemic and residual malaria settings.
format	article
author	Yared Debebe Sharon Rose Hill Habte Tekie Sisay Dugassa Richard J. Hopkins Rickard Ignell
author_facet	Yared Debebe Sharon Rose Hill Habte Tekie Sisay Dugassa Richard J. Hopkins Rickard Ignell
author_sort	Yared Debebe
title	Malaria hotspots explained from the perspective of ecological theory underlying insect foraging
title_short	Malaria hotspots explained from the perspective of ecological theory underlying insect foraging
title_full	Malaria hotspots explained from the perspective of ecological theory underlying insect foraging
title_fullStr	Malaria hotspots explained from the perspective of ecological theory underlying insect foraging
title_full_unstemmed	Malaria hotspots explained from the perspective of ecological theory underlying insect foraging
title_sort	malaria hotspots explained from the perspective of ecological theory underlying insect foraging
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6d8e700c6e2d4f4f87d6bc5658a74b56
work_keys_str_mv	AT yareddebebe malariahotspotsexplainedfromtheperspectiveofecologicaltheoryunderlyinginsectforaging AT sharonrosehill malariahotspotsexplainedfromtheperspectiveofecologicaltheoryunderlyinginsectforaging AT habtetekie malariahotspotsexplainedfromtheperspectiveofecologicaltheoryunderlyinginsectforaging AT sisaydugassa malariahotspotsexplainedfromtheperspectiveofecologicaltheoryunderlyinginsectforaging AT richardjhopkins malariahotspotsexplainedfromtheperspectiveofecologicaltheoryunderlyinginsectforaging AT rickardignell malariahotspotsexplainedfromtheperspectiveofecologicaltheoryunderlyinginsectforaging
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Malaria hotspots explained from the perspective of ecological theory underlying insect foraging

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