Selective single molecule sequencing and assembly of a human Y chromosome of African origin

Selective single molecule sequencing and assembly of a human Y chromosome of African origin

Due to various structural and sequence complexities, the human Y chromosome is challenging to sequence and characterize. Here, the authors develop a strategy to sequence native, unamplified flow sorted Y chromosomes with a nanopore sequencing platform, and report the first assembly of a human Y chro...

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Autores principales: Lukas F. K. Kuderna, Esther Lizano, Eva Julià, Jessica Gomez-Garrido, Aitor Serres-Armero, Martin Kuhlwilm, Regina Antoni Alandes, Marina Alvarez-Estape, David Juan, Heath Simon, Tyler Alioto, Marta Gut, Ivo Gut, Mikkel Heide Schierup, Oscar Fornas, Tomas Marques-Bonet
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/6d90dcc006cb49009ef2eacf2f447a08
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Sumario:Due to various structural and sequence complexities, the human Y chromosome is challenging to sequence and characterize. Here, the authors develop a strategy to sequence native, unamplified flow sorted Y chromosomes with a nanopore sequencing platform, and report the first assembly of a human Y chromosome of African origin.

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