Selective single molecule sequencing and assembly of a human Y chromosome of African origin

Due to various structural and sequence complexities, the human Y chromosome is challenging to sequence and characterize. Here, the authors develop a strategy to sequence native, unamplified flow sorted Y chromosomes with a nanopore sequencing platform, and report the first assembly of a human Y chro...

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Autores principales:	Lukas F. K. Kuderna, Esther Lizano, Eva Julià, Jessica Gomez-Garrido, Aitor Serres-Armero, Martin Kuhlwilm, Regina Antoni Alandes, Marina Alvarez-Estape, David Juan, Heath Simon, Tyler Alioto, Marta Gut, Ivo Gut, Mikkel Heide Schierup, Oscar Fornas, Tomas Marques-Bonet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d90dcc006cb49009ef2eacf2f447a08
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spelling	oai:doaj.org-article:6d90dcc006cb49009ef2eacf2f447a082021-12-02T17:02:03ZSelective single molecule sequencing and assembly of a human Y chromosome of African origin10.1038/s41467-018-07885-52041-1723https://doaj.org/article/6d90dcc006cb49009ef2eacf2f447a082019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07885-5https://doaj.org/toc/2041-1723Due to various structural and sequence complexities, the human Y chromosome is challenging to sequence and characterize. Here, the authors develop a strategy to sequence native, unamplified flow sorted Y chromosomes with a nanopore sequencing platform, and report the first assembly of a human Y chromosome of African origin.Lukas F. K. KudernaEsther LizanoEva JuliàJessica Gomez-GarridoAitor Serres-ArmeroMartin KuhlwilmRegina Antoni AlandesMarina Alvarez-EstapeDavid JuanHeath SimonTyler AliotoMarta GutIvo GutMikkel Heide SchierupOscar FornasTomas Marques-BonetNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lukas F. K. Kuderna Esther Lizano Eva Julià Jessica Gomez-Garrido Aitor Serres-Armero Martin Kuhlwilm Regina Antoni Alandes Marina Alvarez-Estape David Juan Heath Simon Tyler Alioto Marta Gut Ivo Gut Mikkel Heide Schierup Oscar Fornas Tomas Marques-Bonet Selective single molecule sequencing and assembly of a human Y chromosome of African origin
description	Due to various structural and sequence complexities, the human Y chromosome is challenging to sequence and characterize. Here, the authors develop a strategy to sequence native, unamplified flow sorted Y chromosomes with a nanopore sequencing platform, and report the first assembly of a human Y chromosome of African origin.
format	article
author	Lukas F. K. Kuderna Esther Lizano Eva Julià Jessica Gomez-Garrido Aitor Serres-Armero Martin Kuhlwilm Regina Antoni Alandes Marina Alvarez-Estape David Juan Heath Simon Tyler Alioto Marta Gut Ivo Gut Mikkel Heide Schierup Oscar Fornas Tomas Marques-Bonet
author_facet	Lukas F. K. Kuderna Esther Lizano Eva Julià Jessica Gomez-Garrido Aitor Serres-Armero Martin Kuhlwilm Regina Antoni Alandes Marina Alvarez-Estape David Juan Heath Simon Tyler Alioto Marta Gut Ivo Gut Mikkel Heide Schierup Oscar Fornas Tomas Marques-Bonet
author_sort	Lukas F. K. Kuderna
title	Selective single molecule sequencing and assembly of a human Y chromosome of African origin
title_short	Selective single molecule sequencing and assembly of a human Y chromosome of African origin
title_full	Selective single molecule sequencing and assembly of a human Y chromosome of African origin
title_fullStr	Selective single molecule sequencing and assembly of a human Y chromosome of African origin
title_full_unstemmed	Selective single molecule sequencing and assembly of a human Y chromosome of African origin
title_sort	selective single molecule sequencing and assembly of a human y chromosome of african origin
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6d90dcc006cb49009ef2eacf2f447a08
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Selective single molecule sequencing and assembly of a human Y chromosome of African origin

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