Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.

<h4>Background</h4>The aim of this study was to evaluate the proper indication of adjunctive BRAF(V600E) mutation analysis at the time of ultrasound-guided fine-needle aspiration in the diagnosis of thyroid nodules.<h4>Methods</h4>This study included 518 nodules in 479 patien...

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Autores principales:	Jieun Koh, Jong Rak Choi, Kyung Hwa Han, Eun-Kyung Kim, Jung Hyun Yoon, Hee Jung Moon, Jin Young Kwak
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d910b310bf14728995e3b5cbe94dd26
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spelling	oai:doaj.org-article:6d910b310bf14728995e3b5cbe94dd262021-11-18T07:44:18ZProper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.1932-620310.1371/journal.pone.0064505https://doaj.org/article/6d910b310bf14728995e3b5cbe94dd262013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717622/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The aim of this study was to evaluate the proper indication of adjunctive BRAF(V600E) mutation analysis at the time of ultrasound-guided fine-needle aspiration in the diagnosis of thyroid nodules.<h4>Methods</h4>This study included 518 nodules in 479 patients who underwent ultrasound-guided fine-needle aspiration with BRAF(V600E) mutation. We calculated and compared the diagnostic performances of cytology and cytology with BRAF(V600E) mutation analysis to detect malignancy among thyroid nodules according to ultrasound features and size.<h4>Results</h4>Sensitivity, negative predictive value, and accuracy of cytology with BRAF(V600E) mutation analysis were significantly higher than those of cytology alone in thyroid nodules with suspicious ultrasound features, regardless of size. Diagnostic performances did not show significant differences between cytology and cytology with BRAF(V600E) mutation analysis in nodules without any suspicious ultrasound features, regardless of size.<h4>Conclusion</h4>The BRAF(V600E) mutation analysis was a useful adjunctive diagnostic tool in the diagnosis of thyroid nodules with suspicious ultrasound features regardless of size.Jieun KohJong Rak ChoiKyung Hwa HanEun-Kyung KimJung Hyun YoonHee Jung MoonJin Young KwakPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64505 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jieun Koh Jong Rak Choi Kyung Hwa Han Eun-Kyung Kim Jung Hyun Yoon Hee Jung Moon Jin Young Kwak Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.
description	<h4>Background</h4>The aim of this study was to evaluate the proper indication of adjunctive BRAF(V600E) mutation analysis at the time of ultrasound-guided fine-needle aspiration in the diagnosis of thyroid nodules.<h4>Methods</h4>This study included 518 nodules in 479 patients who underwent ultrasound-guided fine-needle aspiration with BRAF(V600E) mutation. We calculated and compared the diagnostic performances of cytology and cytology with BRAF(V600E) mutation analysis to detect malignancy among thyroid nodules according to ultrasound features and size.<h4>Results</h4>Sensitivity, negative predictive value, and accuracy of cytology with BRAF(V600E) mutation analysis were significantly higher than those of cytology alone in thyroid nodules with suspicious ultrasound features, regardless of size. Diagnostic performances did not show significant differences between cytology and cytology with BRAF(V600E) mutation analysis in nodules without any suspicious ultrasound features, regardless of size.<h4>Conclusion</h4>The BRAF(V600E) mutation analysis was a useful adjunctive diagnostic tool in the diagnosis of thyroid nodules with suspicious ultrasound features regardless of size.
format	article
author	Jieun Koh Jong Rak Choi Kyung Hwa Han Eun-Kyung Kim Jung Hyun Yoon Hee Jung Moon Jin Young Kwak
author_facet	Jieun Koh Jong Rak Choi Kyung Hwa Han Eun-Kyung Kim Jung Hyun Yoon Hee Jung Moon Jin Young Kwak
author_sort	Jieun Koh
title	Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.
title_short	Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.
title_full	Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.
title_fullStr	Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.
title_full_unstemmed	Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.
title_sort	proper indication of braf(v600e) mutation testing in fine-needle aspirates of thyroid nodules.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6d910b310bf14728995e3b5cbe94dd26
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Proper indication of BRAF(V600E) mutation testing in fine-needle aspirates of thyroid nodules.

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