Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.

<h4>Background</h4>Chronicity of pain is one of the most interesting questions in chronic pain study. Clinical and experimental data suggest that supraspinal areas responsible for negative emotions such as depression and anxiety contribute to the chronicity of pain. The amygdala is suspe...

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Autores principales:	Zheng Li, Jing Wang, Lin Chen, Meng Zhang, You Wan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d91f4fa718f4908a48d5f6f6ee488ef
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spelling	oai:doaj.org-article:6d91f4fa718f4908a48d5f6f6ee488ef2021-11-18T09:01:14ZBasolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.1932-620310.1371/journal.pone.0070921https://doaj.org/article/6d91f4fa718f4908a48d5f6f6ee488ef2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23940666/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Chronicity of pain is one of the most interesting questions in chronic pain study. Clinical and experimental data suggest that supraspinal areas responsible for negative emotions such as depression and anxiety contribute to the chronicity of pain. The amygdala is suspected to be a potential structure for the pain chronicity due to its critical role in processing negative emotions and pain information.<h4>Objective</h4>This study aimed to investigate whether amygdala or its subregions, the basolateral amygdala (BLA) and the central medial amygdala (CeA), contributes to the pain chronicity in the spared nerve injury (SNI)-induced neuropathic pain model of rats.<h4>Methodology/principal findings</h4>(1) Before the establishment of the SNI-induced neuropathic pain model of rats, lesion of the amygdaloid complex with stereotaxic injection of ibotenic acid (IBO) alleviated mechanical allodynia significantly at days 7 and 14, even no mechanical allodynia at day 28 after SNI; Lesion of the BLA, but not the CeA had similar effects; (2) however, 7 days after SNI when the neuropathic pain model was established, lesion of the amygdala complex or the BLA or the CeA, mechanical allodynia was not affected.<h4>Conclusion</h4>These results suggest that BLA activities in the early stage after nerve injury might be crucial to the development of pain chronicity, and amygdala-related negative emotions and pain-related memories could promote pain chronicity.Zheng LiJing WangLin ChenMeng ZhangYou WanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e70921 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zheng Li Jing Wang Lin Chen Meng Zhang You Wan Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.
description	<h4>Background</h4>Chronicity of pain is one of the most interesting questions in chronic pain study. Clinical and experimental data suggest that supraspinal areas responsible for negative emotions such as depression and anxiety contribute to the chronicity of pain. The amygdala is suspected to be a potential structure for the pain chronicity due to its critical role in processing negative emotions and pain information.<h4>Objective</h4>This study aimed to investigate whether amygdala or its subregions, the basolateral amygdala (BLA) and the central medial amygdala (CeA), contributes to the pain chronicity in the spared nerve injury (SNI)-induced neuropathic pain model of rats.<h4>Methodology/principal findings</h4>(1) Before the establishment of the SNI-induced neuropathic pain model of rats, lesion of the amygdaloid complex with stereotaxic injection of ibotenic acid (IBO) alleviated mechanical allodynia significantly at days 7 and 14, even no mechanical allodynia at day 28 after SNI; Lesion of the BLA, but not the CeA had similar effects; (2) however, 7 days after SNI when the neuropathic pain model was established, lesion of the amygdala complex or the BLA or the CeA, mechanical allodynia was not affected.<h4>Conclusion</h4>These results suggest that BLA activities in the early stage after nerve injury might be crucial to the development of pain chronicity, and amygdala-related negative emotions and pain-related memories could promote pain chronicity.
format	article
author	Zheng Li Jing Wang Lin Chen Meng Zhang You Wan
author_facet	Zheng Li Jing Wang Lin Chen Meng Zhang You Wan
author_sort	Zheng Li
title	Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.
title_short	Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.
title_full	Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.
title_fullStr	Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.
title_full_unstemmed	Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.
title_sort	basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6d91f4fa718f4908a48d5f6f6ee488ef
work_keys_str_mv	AT zhengli basolateralamygdalalesioninhibitsthedevelopmentofpainchronicityinneuropathicpainrats AT jingwang basolateralamygdalalesioninhibitsthedevelopmentofpainchronicityinneuropathicpainrats AT linchen basolateralamygdalalesioninhibitsthedevelopmentofpainchronicityinneuropathicpainrats AT mengzhang basolateralamygdalalesioninhibitsthedevelopmentofpainchronicityinneuropathicpainrats AT youwan basolateralamygdalalesioninhibitsthedevelopmentofpainchronicityinneuropathicpainrats
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Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats.

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