Isobutanol production freed from biological limits using synthetic biochemistry

A cell free or synthetic biochemistry approach offers a way to circumvent the many constraints of living cells. Here, the authors demonstrate, via enzyme and process enhancements, the production of isobutanol with the metrics exceeding highly developed ethanol fermentation.

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Autores principales:	Saken Sherkhanov, Tyler P. Korman, Sum Chan, Salem Faham, Hongjiang Liu, Michael R. Sawaya, Wan-Ting Hsu, Ellee Vikram, Tiffany Cheng, James U. Bowie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d928504ca27437ea5b6a0df6826c323
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spelling	oai:doaj.org-article:6d928504ca27437ea5b6a0df6826c3232021-12-02T18:53:11ZIsobutanol production freed from biological limits using synthetic biochemistry10.1038/s41467-020-18124-12041-1723https://doaj.org/article/6d928504ca27437ea5b6a0df6826c3232020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18124-1https://doaj.org/toc/2041-1723A cell free or synthetic biochemistry approach offers a way to circumvent the many constraints of living cells. Here, the authors demonstrate, via enzyme and process enhancements, the production of isobutanol with the metrics exceeding highly developed ethanol fermentation.Saken SherkhanovTyler P. KormanSum ChanSalem FahamHongjiang LiuMichael R. SawayaWan-Ting HsuEllee VikramTiffany ChengJames U. BowieNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saken Sherkhanov Tyler P. Korman Sum Chan Salem Faham Hongjiang Liu Michael R. Sawaya Wan-Ting Hsu Ellee Vikram Tiffany Cheng James U. Bowie Isobutanol production freed from biological limits using synthetic biochemistry
description	A cell free or synthetic biochemistry approach offers a way to circumvent the many constraints of living cells. Here, the authors demonstrate, via enzyme and process enhancements, the production of isobutanol with the metrics exceeding highly developed ethanol fermentation.
format	article
author	Saken Sherkhanov Tyler P. Korman Sum Chan Salem Faham Hongjiang Liu Michael R. Sawaya Wan-Ting Hsu Ellee Vikram Tiffany Cheng James U. Bowie
author_facet	Saken Sherkhanov Tyler P. Korman Sum Chan Salem Faham Hongjiang Liu Michael R. Sawaya Wan-Ting Hsu Ellee Vikram Tiffany Cheng James U. Bowie
author_sort	Saken Sherkhanov
title	Isobutanol production freed from biological limits using synthetic biochemistry
title_short	Isobutanol production freed from biological limits using synthetic biochemistry
title_full	Isobutanol production freed from biological limits using synthetic biochemistry
title_fullStr	Isobutanol production freed from biological limits using synthetic biochemistry
title_full_unstemmed	Isobutanol production freed from biological limits using synthetic biochemistry
title_sort	isobutanol production freed from biological limits using synthetic biochemistry
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6d928504ca27437ea5b6a0df6826c323
work_keys_str_mv	AT sakensherkhanov isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry AT tylerpkorman isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry AT sumchan isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry AT salemfaham isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry AT hongjiangliu isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry AT michaelrsawaya isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry AT wantinghsu isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry AT elleevikram isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry AT tiffanycheng isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry AT jamesubowie isobutanolproductionfreedfrombiologicallimitsusingsyntheticbiochemistry
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Isobutanol production freed from biological limits using synthetic biochemistry

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