A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure

Khodadadei et al. investigate the mechanisms underlying cerebral shunt failure using a microfluidic chip to simulate shear forces in the shunt. Employing total internal reflection fluorescence imaging, their findings indicate that astrocyte interleukin-6 cytokine secretions increase under higher shu...

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Autores principales:	Fatemeh Khodadadei, Allen P. Liu, Carolyn A. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6d92a8dbeefe415a8009577049576d65
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spelling	oai:doaj.org-article:6d92a8dbeefe415a8009577049576d652021-12-02T16:35:55ZA high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure10.1038/s42003-021-01888-72399-3642https://doaj.org/article/6d92a8dbeefe415a8009577049576d652021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01888-7https://doaj.org/toc/2399-3642Khodadadei et al. investigate the mechanisms underlying cerebral shunt failure using a microfluidic chip to simulate shear forces in the shunt. Employing total internal reflection fluorescence imaging, their findings indicate that astrocyte interleukin-6 cytokine secretions increase under higher shunt shear stresses, informing future shunt design and potential drug therapies to reduce shunt failure in patients.Fatemeh KhodadadeiAllen P. LiuCarolyn A. HarrisNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Fatemeh Khodadadei Allen P. Liu Carolyn A. Harris A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure
description	Khodadadei et al. investigate the mechanisms underlying cerebral shunt failure using a microfluidic chip to simulate shear forces in the shunt. Employing total internal reflection fluorescence imaging, their findings indicate that astrocyte interleukin-6 cytokine secretions increase under higher shunt shear stresses, informing future shunt design and potential drug therapies to reduce shunt failure in patients.
format	article
author	Fatemeh Khodadadei Allen P. Liu Carolyn A. Harris
author_facet	Fatemeh Khodadadei Allen P. Liu Carolyn A. Harris
author_sort	Fatemeh Khodadadei
title	A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure
title_short	A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure
title_full	A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure
title_fullStr	A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure
title_full_unstemmed	A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure
title_sort	high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6d92a8dbeefe415a8009577049576d65
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A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure

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