Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children
Objectives: The World Health Organization recommends a 2-dose rabies pre-exposure prophylaxis (PrEP) regimen. This study aimed to compare the immunogenicity of rabies PrEP regimens co-administered with inactivated quadrivalent influenza vaccine (IIV4). Methods: Children aged 3 to 9 years were random...
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2021
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oai:doaj.org-article:6d9801c6b7bc4308b1f59922fb6dcaa42021-11-30T04:14:16ZImmunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children1201-971210.1016/j.ijid.2021.09.025https://doaj.org/article/6d9801c6b7bc4308b1f59922fb6dcaa42021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007360https://doaj.org/toc/1201-9712Objectives: The World Health Organization recommends a 2-dose rabies pre-exposure prophylaxis (PrEP) regimen. This study aimed to compare the immunogenicity of rabies PrEP regimens co-administered with inactivated quadrivalent influenza vaccine (IIV4). Methods: Children aged 3 to 9 years were randomly assigned (2:2:1) to receive 0.25 mL of chromatographically purified Vero cell rabies vaccine intramuscularly: Group A at day 0, 7 with IIV4; Group B at day 0, 28 with IIV4; Group C at day 0, 7. A booster-dose of CPRV was given on day 365. Primary outcome was the proportion of children with protective rabies virus neutralizing antibody (RVNA) ≥ 0.5 IU/mL, on day 42 and 7 days post-booster. Results: From November 2019 to January 2020; 100 children with a median age (IQR) of 5.4 years (4.8-7.3) were enrolled. All participants achieved protective RVNA titers on day 42 and 7-days post booster. Geometric mean titers (GMT) at day 42 were Group A, 8.98(95%CI 7.06-11.42); Group B, 23.89(95%CI 19.33-29.51); Group C, 9.94(95%CI 7.03-14.06). Likewise, RVNA GMT at 7 days post-booster were Group A, 42.53(95%CI 18.41-66.64); Group B, 23.19(95%CI 17.28-29.10); Group C, 57.75 (95%CI 35.86-79.67). Conclusions: The 2-dose PrEP regimen of rabies vaccine produces adequate immune response either 0,7 or 0, 28 regimens.Napaporn ChantasrisawadWatsamon JantarabenjakulSuvaporn AnugulruengkittSuda PunrinKornvika LimsuwunPanadda SawangsinthChayapa PhasomsapJiratchaya SophonphanChitsanu PancharoenThanyawee PuthanakitElsevierarticleRabies vaccinePre-exposure rabies prophylaxisInactivated quadrivalent influenza vaccineChildrenInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 89-95 (2021) |
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DOAJ |
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EN |
| topic |
Rabies vaccine Pre-exposure rabies prophylaxis Inactivated quadrivalent influenza vaccine Children Infectious and parasitic diseases RC109-216 |
| spellingShingle |
Rabies vaccine Pre-exposure rabies prophylaxis Inactivated quadrivalent influenza vaccine Children Infectious and parasitic diseases RC109-216 Napaporn Chantasrisawad Watsamon Jantarabenjakul Suvaporn Anugulruengkitt Suda Punrin Kornvika Limsuwun Panadda Sawangsinth Chayapa Phasomsap Jiratchaya Sophonphan Chitsanu Pancharoen Thanyawee Puthanakit Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
| description |
Objectives: The World Health Organization recommends a 2-dose rabies pre-exposure prophylaxis (PrEP) regimen. This study aimed to compare the immunogenicity of rabies PrEP regimens co-administered with inactivated quadrivalent influenza vaccine (IIV4). Methods: Children aged 3 to 9 years were randomly assigned (2:2:1) to receive 0.25 mL of chromatographically purified Vero cell rabies vaccine intramuscularly: Group A at day 0, 7 with IIV4; Group B at day 0, 28 with IIV4; Group C at day 0, 7. A booster-dose of CPRV was given on day 365. Primary outcome was the proportion of children with protective rabies virus neutralizing antibody (RVNA) ≥ 0.5 IU/mL, on day 42 and 7 days post-booster. Results: From November 2019 to January 2020; 100 children with a median age (IQR) of 5.4 years (4.8-7.3) were enrolled. All participants achieved protective RVNA titers on day 42 and 7-days post booster. Geometric mean titers (GMT) at day 42 were Group A, 8.98(95%CI 7.06-11.42); Group B, 23.89(95%CI 19.33-29.51); Group C, 9.94(95%CI 7.03-14.06). Likewise, RVNA GMT at 7 days post-booster were Group A, 42.53(95%CI 18.41-66.64); Group B, 23.19(95%CI 17.28-29.10); Group C, 57.75 (95%CI 35.86-79.67). Conclusions: The 2-dose PrEP regimen of rabies vaccine produces adequate immune response either 0,7 or 0, 28 regimens. |
| format |
article |
| author |
Napaporn Chantasrisawad Watsamon Jantarabenjakul Suvaporn Anugulruengkitt Suda Punrin Kornvika Limsuwun Panadda Sawangsinth Chayapa Phasomsap Jiratchaya Sophonphan Chitsanu Pancharoen Thanyawee Puthanakit |
| author_facet |
Napaporn Chantasrisawad Watsamon Jantarabenjakul Suvaporn Anugulruengkitt Suda Punrin Kornvika Limsuwun Panadda Sawangsinth Chayapa Phasomsap Jiratchaya Sophonphan Chitsanu Pancharoen Thanyawee Puthanakit |
| author_sort |
Napaporn Chantasrisawad |
| title |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
| title_short |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
| title_full |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
| title_fullStr |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
| title_full_unstemmed |
Immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
| title_sort |
immunogenicity of 2-dose pre-exposure rabies vaccine co-administered with quadrivalent influenza vaccine in children |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/6d9801c6b7bc4308b1f59922fb6dcaa4 |
| work_keys_str_mv |
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