Immunological indexes in evaluation of chronic pain syndrome”, Medical Immunology (Russia)

Chronic pain in humans remains a challenge for diagnosis. It manifests itself as multicomponent symptoms and leads to dysregulation of many biochemical systems. The approaches based on measuring the neurohumoral factors regulating transmission of a pain signal, are promising for the pain eva...

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Autores principales:	M. A. Мyagkova, S. N. Petrochenko, E. A. Orlova, A. S. Krylov, I. A. Moseykin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	chronic pain syndrome serotonin dopamine natural antibodies enzyme immunoassay Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6d9a4203f62a4eb4840cc86e9c3529af
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spelling	oai:doaj.org-article:6d9a4203f62a4eb4840cc86e9c3529af2021-11-18T08:03:50ZImmunological indexes in evaluation of chronic pain syndrome”, Medical Immunology (Russia)1563-06252313-741Xhttps://doaj.org/article/6d9a4203f62a4eb4840cc86e9c3529af2020-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1995https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XChronic pain in humans remains a challenge for diagnosis. It manifests itself as multicomponent symptoms and leads to dysregulation of many biochemical systems. The approaches based on measuring the neurohumoral factors regulating transmission of a pain signal, are promising for the pain evaluation. These include immunological parameters, such as natural antibodies (e-At), which can specifically interact with endogenous bioregulators of pain impulse (EB), especially, with serotonin, dopamine, and modulate the process of pain development. Antibody metabolism is characterized by longer circulation in the bloodstream as compared to EB. Therefore, the content of e-At to EB reflects long-term changes in the body upon development of chronic pain. Detection of relationships between their level and the course of treatment will allow us to establish the prognostic role of immunological parameters in objective assessment of pain status of patients.The study included 136 patients (70 women and 66 men) with chronic pain syndrome. The patients were subjected to assays of e-At to dopamine, serotonin, and a survey using a visual analogue scale, in order to assess the intensity of pain. The indexes were measured in the course of treatment (1st, 10th , and 21st days).As a result, a significant decrease in pain intensity was found in 63% of women and in 71% of males. E-At levels in patients admitted for treatment were initially mostly elevated and high. The dynamics of e-At change was multidirectional. On the day 21, an increase in the occurrence of normal levels of e-At to serotonin was detected in 52% of women and in 59% of men. The content of e-At to dopamine in this period was recorded at a normal level in 56% of women, however, being increased in men (50% of cases), with high levels in 17% of males.Thus, examination of patients with CHD showed that, against the background of ongoing therapy, pain intensity decreases, and antibodies to pain mediators may continue to circulate at elevated concentrations. It is likely that the body maintains pathologically elevated levels of e-At to EB, reflecting the content of EB itself, contributes to prolongation of CHD. Monitoring individual profile of the immunological parameters of e-Ab to EB in patients may have prognostic value for choosing an effective, personalized treatment program.M. A. МyagkovaS. N. PetrochenkoE. A. OrlovaA. S. KrylovI. A. MoseykinSPb RAACIarticlechronic pain syndromeserotonindopaminenatural antibodiesenzyme immunoassayImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 4, Pp 685-692 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic pain syndrome serotonin dopamine natural antibodies enzyme immunoassay Immunologic diseases. Allergy RC581-607
spellingShingle	chronic pain syndrome serotonin dopamine natural antibodies enzyme immunoassay Immunologic diseases. Allergy RC581-607 M. A. Мyagkova S. N. Petrochenko E. A. Orlova A. S. Krylov I. A. Moseykin Immunological indexes in evaluation of chronic pain syndrome”, Medical Immunology (Russia)
description	Chronic pain in humans remains a challenge for diagnosis. It manifests itself as multicomponent symptoms and leads to dysregulation of many biochemical systems. The approaches based on measuring the neurohumoral factors regulating transmission of a pain signal, are promising for the pain evaluation. These include immunological parameters, such as natural antibodies (e-At), which can specifically interact with endogenous bioregulators of pain impulse (EB), especially, with serotonin, dopamine, and modulate the process of pain development. Antibody metabolism is characterized by longer circulation in the bloodstream as compared to EB. Therefore, the content of e-At to EB reflects long-term changes in the body upon development of chronic pain. Detection of relationships between their level and the course of treatment will allow us to establish the prognostic role of immunological parameters in objective assessment of pain status of patients.The study included 136 patients (70 women and 66 men) with chronic pain syndrome. The patients were subjected to assays of e-At to dopamine, serotonin, and a survey using a visual analogue scale, in order to assess the intensity of pain. The indexes were measured in the course of treatment (1st, 10th , and 21st days).As a result, a significant decrease in pain intensity was found in 63% of women and in 71% of males. E-At levels in patients admitted for treatment were initially mostly elevated and high. The dynamics of e-At change was multidirectional. On the day 21, an increase in the occurrence of normal levels of e-At to serotonin was detected in 52% of women and in 59% of men. The content of e-At to dopamine in this period was recorded at a normal level in 56% of women, however, being increased in men (50% of cases), with high levels in 17% of males.Thus, examination of patients with CHD showed that, against the background of ongoing therapy, pain intensity decreases, and antibodies to pain mediators may continue to circulate at elevated concentrations. It is likely that the body maintains pathologically elevated levels of e-At to EB, reflecting the content of EB itself, contributes to prolongation of CHD. Monitoring individual profile of the immunological parameters of e-Ab to EB in patients may have prognostic value for choosing an effective, personalized treatment program.
format	article
author	M. A. Мyagkova S. N. Petrochenko E. A. Orlova A. S. Krylov I. A. Moseykin
author_facet	M. A. Мyagkova S. N. Petrochenko E. A. Orlova A. S. Krylov I. A. Moseykin
author_sort	M. A. Мyagkova
title	Immunological indexes in evaluation of chronic pain syndrome”, Medical Immunology (Russia)
title_short	Immunological indexes in evaluation of chronic pain syndrome”, Medical Immunology (Russia)
title_full	Immunological indexes in evaluation of chronic pain syndrome”, Medical Immunology (Russia)
title_fullStr	Immunological indexes in evaluation of chronic pain syndrome”, Medical Immunology (Russia)
title_full_unstemmed	Immunological indexes in evaluation of chronic pain syndrome”, Medical Immunology (Russia)
title_sort	immunological indexes in evaluation of chronic pain syndrome”, medical immunology (russia)
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/6d9a4203f62a4eb4840cc86e9c3529af
work_keys_str_mv	AT mamyagkova immunologicalindexesinevaluationofchronicpainsyndromemedicalimmunologyrussia AT snpetrochenko immunologicalindexesinevaluationofchronicpainsyndromemedicalimmunologyrussia AT eaorlova immunologicalindexesinevaluationofchronicpainsyndromemedicalimmunologyrussia AT askrylov immunologicalindexesinevaluationofchronicpainsyndromemedicalimmunologyrussia AT iamoseykin immunologicalindexesinevaluationofchronicpainsyndromemedicalimmunologyrussia
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Immunological indexes in evaluation of chronic pain syndrome”, Medical Immunology (Russia)

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