Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report

Abstract Background Indapamide, a sulfonamide diuretic used to treat hypertension, has been reported to have ocular side effects of acute angle-closure glaucoma, transient myopia and choroidal effusion whose immediate etiology is uncertain. This report aims to clarify the nature of indapamide-induce...

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Autores principales:	Shizuka Takahashi, Shinichi Usui, Noriyasu Hashida, Hiroshi Kubota, Kentaro Nishida, Hirokazu Sakaguchi, Kohji Nishida
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Acute angle-closure glaucoma Ciliary body edema Drug-induced choroidal effusion Indapamide Multimodal imaging Myopia Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6d9be013e02c43a2a696d5ebe9ab57ef
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spelling	oai:doaj.org-article:6d9be013e02c43a2a696d5ebe9ab57ef2021-11-08T11:19:31ZMultimodal imaging of indapamide-induced bilateral choroidal effusion: a case report10.1186/s12886-021-02147-31471-2415https://doaj.org/article/6d9be013e02c43a2a696d5ebe9ab57ef2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12886-021-02147-3https://doaj.org/toc/1471-2415Abstract Background Indapamide, a sulfonamide diuretic used to treat hypertension, has been reported to have ocular side effects of acute angle-closure glaucoma, transient myopia and choroidal effusion whose immediate etiology is uncertain. This report aims to clarify the nature of indapamide-induced edema of the entire eyeball using multimodal imaging. Case presentation A 60-year-old woman who was following a long-term carbohydrate-restricted diet and receiving oral treatment for hypertension was referred to our department for eye pain. Indapamide (1 mg daily) was prescribed for uncontrolled hypertension 5 days before her visit; she took the medication for only 3 days and then stopped due to dry eye. However, she began to feel eye pain the day after her last dose, and the pain gradually intensified. She experienced no decrease in visual acuity at the initial visit; however, an extremely shallow anterior chamber was observed in both eyes, along with a slight increase in intraocular pressure. For differential diagnosis, ocular manifestations were evaluated with wide-field fundus photography, optical coherence tomography (OCT) of both anterior and posterior segments, fluorescein / indocyanine green angiography, ultrasound biomicroscopy and head magnetic resonance, showing edema of the entire eyeball. Treatment with tropicamide and phenylephrine hydrochloride drops resulted in rapid recovery of the anterior chamber depth and disappearance of the choroidal effusion within 3 days. Conclusions Multimodal imaging is useful for diagnosing drug-induced choroidal effusion by evaluating ocular conditions before and after treatment.Shizuka TakahashiShinichi UsuiNoriyasu HashidaHiroshi KubotaKentaro NishidaHirokazu SakaguchiKohji NishidaBMCarticleAcute angle-closure glaucomaCiliary body edemaDrug-induced choroidal effusionIndapamideMultimodal imagingMyopiaOphthalmologyRE1-994ENBMC Ophthalmology, Vol 21, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute angle-closure glaucoma Ciliary body edema Drug-induced choroidal effusion Indapamide Multimodal imaging Myopia Ophthalmology RE1-994
spellingShingle	Acute angle-closure glaucoma Ciliary body edema Drug-induced choroidal effusion Indapamide Multimodal imaging Myopia Ophthalmology RE1-994 Shizuka Takahashi Shinichi Usui Noriyasu Hashida Hiroshi Kubota Kentaro Nishida Hirokazu Sakaguchi Kohji Nishida Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report
description	Abstract Background Indapamide, a sulfonamide diuretic used to treat hypertension, has been reported to have ocular side effects of acute angle-closure glaucoma, transient myopia and choroidal effusion whose immediate etiology is uncertain. This report aims to clarify the nature of indapamide-induced edema of the entire eyeball using multimodal imaging. Case presentation A 60-year-old woman who was following a long-term carbohydrate-restricted diet and receiving oral treatment for hypertension was referred to our department for eye pain. Indapamide (1 mg daily) was prescribed for uncontrolled hypertension 5 days before her visit; she took the medication for only 3 days and then stopped due to dry eye. However, she began to feel eye pain the day after her last dose, and the pain gradually intensified. She experienced no decrease in visual acuity at the initial visit; however, an extremely shallow anterior chamber was observed in both eyes, along with a slight increase in intraocular pressure. For differential diagnosis, ocular manifestations were evaluated with wide-field fundus photography, optical coherence tomography (OCT) of both anterior and posterior segments, fluorescein / indocyanine green angiography, ultrasound biomicroscopy and head magnetic resonance, showing edema of the entire eyeball. Treatment with tropicamide and phenylephrine hydrochloride drops resulted in rapid recovery of the anterior chamber depth and disappearance of the choroidal effusion within 3 days. Conclusions Multimodal imaging is useful for diagnosing drug-induced choroidal effusion by evaluating ocular conditions before and after treatment.
format	article
author	Shizuka Takahashi Shinichi Usui Noriyasu Hashida Hiroshi Kubota Kentaro Nishida Hirokazu Sakaguchi Kohji Nishida
author_facet	Shizuka Takahashi Shinichi Usui Noriyasu Hashida Hiroshi Kubota Kentaro Nishida Hirokazu Sakaguchi Kohji Nishida
author_sort	Shizuka Takahashi
title	Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report
title_short	Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report
title_full	Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report
title_fullStr	Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report
title_full_unstemmed	Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report
title_sort	multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6d9be013e02c43a2a696d5ebe9ab57ef
work_keys_str_mv	AT shizukatakahashi multimodalimagingofindapamideinducedbilateralchoroidaleffusionacasereport AT shinichiusui multimodalimagingofindapamideinducedbilateralchoroidaleffusionacasereport AT noriyasuhashida multimodalimagingofindapamideinducedbilateralchoroidaleffusionacasereport AT hiroshikubota multimodalimagingofindapamideinducedbilateralchoroidaleffusionacasereport AT kentaronishida multimodalimagingofindapamideinducedbilateralchoroidaleffusionacasereport AT hirokazusakaguchi multimodalimagingofindapamideinducedbilateralchoroidaleffusionacasereport AT kohjinishida multimodalimagingofindapamideinducedbilateralchoroidaleffusionacasereport
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Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report

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