Exo70 is an independent prognostic factor in colon cancer

Abstract Exo70, a key component of the Exocyst complex, plays important roles in human cancer progression beyond exocytosis. However, the expression of Exo70 and its prognostic value for patients with colon cancer has not been well investigated to date. In this study, we observed that the mRNA and p...

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Autores principales:	Li Xiao, Kaifeng Zheng, Xia Lv, Jihuan Hou, Liang Xu, Yujie Zhao, Fei Song, Yaqiong Fan, Hanwei Cao, Wenqing Zhang, Xiaoting Hong, Yan-yan Zhan, Tianhui Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6da550d0c62d4b198d039f062b907a59
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spelling	oai:doaj.org-article:6da550d0c62d4b198d039f062b907a592021-12-02T15:05:48ZExo70 is an independent prognostic factor in colon cancer10.1038/s41598-017-05308-x2045-2322https://doaj.org/article/6da550d0c62d4b198d039f062b907a592017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05308-xhttps://doaj.org/toc/2045-2322Abstract Exo70, a key component of the Exocyst complex, plays important roles in human cancer progression beyond exocytosis. However, the expression of Exo70 and its prognostic value for patients with colon cancer has not been well investigated to date. In this study, we observed that the mRNA and protein levels of Exo70 were upregulated in 11 of 13 colon cancer tissues, compared with their normal counterparts, which was validated by immunohistochemical analysis in a tissue microarray containing 89 pairs of colon cancer tissues and the matched adjacent normal tissues. Statistical analysis revealed that Exo70 expression is positively correlated with tumor size, invasion depth, TNM stage and distant metastasis. Kaplan-Meier survival analysis showed that colon cancer patients with higher Exo70 expression have a poorer clinical outcome than those with lower Exo70 expression. Multivariate Cox regression analysis revealed that Exo70, age and distant metastasis were there independent prognostic factors for overall survival rate of colon cancer patients. Through gain- and loss of Exo70 in colon cancer cells, we found that Exo70 could enhance the migration ability of colon cancer cells. Taken together, our studies revealed that Exo70 might be a promising negative prognostic factor and a potential therapeutic target for colon cancer.Li XiaoKaifeng ZhengXia LvJihuan HouLiang XuYujie ZhaoFei SongYaqiong FanHanwei CaoWenqing ZhangXiaoting HongYan-yan ZhanTianhui HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Xiao Kaifeng Zheng Xia Lv Jihuan Hou Liang Xu Yujie Zhao Fei Song Yaqiong Fan Hanwei Cao Wenqing Zhang Xiaoting Hong Yan-yan Zhan Tianhui Hu Exo70 is an independent prognostic factor in colon cancer
description	Abstract Exo70, a key component of the Exocyst complex, plays important roles in human cancer progression beyond exocytosis. However, the expression of Exo70 and its prognostic value for patients with colon cancer has not been well investigated to date. In this study, we observed that the mRNA and protein levels of Exo70 were upregulated in 11 of 13 colon cancer tissues, compared with their normal counterparts, which was validated by immunohistochemical analysis in a tissue microarray containing 89 pairs of colon cancer tissues and the matched adjacent normal tissues. Statistical analysis revealed that Exo70 expression is positively correlated with tumor size, invasion depth, TNM stage and distant metastasis. Kaplan-Meier survival analysis showed that colon cancer patients with higher Exo70 expression have a poorer clinical outcome than those with lower Exo70 expression. Multivariate Cox regression analysis revealed that Exo70, age and distant metastasis were there independent prognostic factors for overall survival rate of colon cancer patients. Through gain- and loss of Exo70 in colon cancer cells, we found that Exo70 could enhance the migration ability of colon cancer cells. Taken together, our studies revealed that Exo70 might be a promising negative prognostic factor and a potential therapeutic target for colon cancer.
format	article
author	Li Xiao Kaifeng Zheng Xia Lv Jihuan Hou Liang Xu Yujie Zhao Fei Song Yaqiong Fan Hanwei Cao Wenqing Zhang Xiaoting Hong Yan-yan Zhan Tianhui Hu
author_facet	Li Xiao Kaifeng Zheng Xia Lv Jihuan Hou Liang Xu Yujie Zhao Fei Song Yaqiong Fan Hanwei Cao Wenqing Zhang Xiaoting Hong Yan-yan Zhan Tianhui Hu
author_sort	Li Xiao
title	Exo70 is an independent prognostic factor in colon cancer
title_short	Exo70 is an independent prognostic factor in colon cancer
title_full	Exo70 is an independent prognostic factor in colon cancer
title_fullStr	Exo70 is an independent prognostic factor in colon cancer
title_full_unstemmed	Exo70 is an independent prognostic factor in colon cancer
title_sort	exo70 is an independent prognostic factor in colon cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6da550d0c62d4b198d039f062b907a59
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_version_	1718388709795037184

Exo70 is an independent prognostic factor in colon cancer

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