Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ag...
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Nature Portfolio
2020
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oai:doaj.org-article:6da73ceced984a059e48b4f7619a183a2021-12-02T15:02:30ZMetabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality10.1038/s41467-020-16633-72041-1723https://doaj.org/article/6da73ceced984a059e48b4f7619a183a2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16633-7https://doaj.org/toc/2041-1723Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ageing and IL-15 signalling and not directly by FAO.Kylie M. QuinnTabinda HussainFelix KrausLuke E. FormosaWai K. LamMichael J. DagleyEleanor C. SaundersLisa M. AssmusErica Wynne-JonesLiyen LohCarolien E. van de SandtLucy CooperKim L. Good-JacobsonKatherine KedzierskaLaura K. MackayMalcolm J. McConvilleGeorg RammMichael T. RyanNicole L. La GrutaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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Science Q Kylie M. Quinn Tabinda Hussain Felix Kraus Luke E. Formosa Wai K. Lam Michael J. Dagley Eleanor C. Saunders Lisa M. Assmus Erica Wynne-Jones Liyen Loh Carolien E. van de Sandt Lucy Cooper Kim L. Good-Jacobson Katherine Kedzierska Laura K. Mackay Malcolm J. McConville Georg Ramm Michael T. Ryan Nicole L. La Gruta Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality |
description |
Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ageing and IL-15 signalling and not directly by FAO. |
format |
article |
author |
Kylie M. Quinn Tabinda Hussain Felix Kraus Luke E. Formosa Wai K. Lam Michael J. Dagley Eleanor C. Saunders Lisa M. Assmus Erica Wynne-Jones Liyen Loh Carolien E. van de Sandt Lucy Cooper Kim L. Good-Jacobson Katherine Kedzierska Laura K. Mackay Malcolm J. McConville Georg Ramm Michael T. Ryan Nicole L. La Gruta |
author_facet |
Kylie M. Quinn Tabinda Hussain Felix Kraus Luke E. Formosa Wai K. Lam Michael J. Dagley Eleanor C. Saunders Lisa M. Assmus Erica Wynne-Jones Liyen Loh Carolien E. van de Sandt Lucy Cooper Kim L. Good-Jacobson Katherine Kedzierska Laura K. Mackay Malcolm J. McConville Georg Ramm Michael T. Ryan Nicole L. La Gruta |
author_sort |
Kylie M. Quinn |
title |
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality |
title_short |
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality |
title_full |
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality |
title_fullStr |
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality |
title_full_unstemmed |
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality |
title_sort |
metabolic characteristics of cd8+ t cell subsets in young and aged individuals are not predictive of functionality |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/6da73ceced984a059e48b4f7619a183a |
work_keys_str_mv |
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