Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ag...

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Auteurs principaux:	Kylie M. Quinn, Tabinda Hussain, Felix Kraus, Luke E. Formosa, Wai K. Lam, Michael J. Dagley, Eleanor C. Saunders, Lisa M. Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E. van de Sandt, Lucy Cooper, Kim L. Good-Jacobson, Katherine Kedzierska, Laura K. Mackay, Malcolm J. McConville, Georg Ramm, Michael T. Ryan, Nicole L. La Gruta
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/6da73ceced984a059e48b4f7619a183a
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spelling	oai:doaj.org-article:6da73ceced984a059e48b4f7619a183a2021-12-02T15:02:30ZMetabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality10.1038/s41467-020-16633-72041-1723https://doaj.org/article/6da73ceced984a059e48b4f7619a183a2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16633-7https://doaj.org/toc/2041-1723Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ageing and IL-15 signalling and not directly by FAO.Kylie M. QuinnTabinda HussainFelix KrausLuke E. FormosaWai K. LamMichael J. DagleyEleanor C. SaundersLisa M. AssmusErica Wynne-JonesLiyen LohCarolien E. van de SandtLucy CooperKim L. Good-JacobsonKatherine KedzierskaLaura K. MackayMalcolm J. McConvilleGeorg RammMichael T. RyanNicole L. La GrutaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kylie M. Quinn Tabinda Hussain Felix Kraus Luke E. Formosa Wai K. Lam Michael J. Dagley Eleanor C. Saunders Lisa M. Assmus Erica Wynne-Jones Liyen Loh Carolien E. van de Sandt Lucy Cooper Kim L. Good-Jacobson Katherine Kedzierska Laura K. Mackay Malcolm J. McConville Georg Ramm Michael T. Ryan Nicole L. La Gruta Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
description	Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have high SRC, a metabolic state that it is affected by ageing and IL-15 signalling and not directly by FAO.
format	article
author	Kylie M. Quinn Tabinda Hussain Felix Kraus Luke E. Formosa Wai K. Lam Michael J. Dagley Eleanor C. Saunders Lisa M. Assmus Erica Wynne-Jones Liyen Loh Carolien E. van de Sandt Lucy Cooper Kim L. Good-Jacobson Katherine Kedzierska Laura K. Mackay Malcolm J. McConville Georg Ramm Michael T. Ryan Nicole L. La Gruta
author_facet	Kylie M. Quinn Tabinda Hussain Felix Kraus Luke E. Formosa Wai K. Lam Michael J. Dagley Eleanor C. Saunders Lisa M. Assmus Erica Wynne-Jones Liyen Loh Carolien E. van de Sandt Lucy Cooper Kim L. Good-Jacobson Katherine Kedzierska Laura K. Mackay Malcolm J. McConville Georg Ramm Michael T. Ryan Nicole L. La Gruta
author_sort	Kylie M. Quinn
title	Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
title_short	Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
title_full	Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
title_fullStr	Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
title_full_unstemmed	Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
title_sort	metabolic characteristics of cd8+ t cell subsets in young and aged individuals are not predictive of functionality
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6da73ceced984a059e48b4f7619a183a
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Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

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