YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with improved insulin secretion.

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Autores principales:	Edwin A. Rosado-Olivieri, Kendall Anderson, Jennifer H. Kenty, Douglas A. Melton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6daa58996f78488b8379255d83f5ea05
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spelling	oai:doaj.org-article:6daa58996f78488b8379255d83f5ea052021-12-02T15:36:22ZYAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells10.1038/s41467-019-09404-62041-1723https://doaj.org/article/6daa58996f78488b8379255d83f5ea052019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09404-6https://doaj.org/toc/2041-1723Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with improved insulin secretion.Edwin A. Rosado-OlivieriKendall AndersonJennifer H. KentyDouglas A. MeltonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edwin A. Rosado-Olivieri Kendall Anderson Jennifer H. Kenty Douglas A. Melton YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
description	Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with improved insulin secretion.
format	article
author	Edwin A. Rosado-Olivieri Kendall Anderson Jennifer H. Kenty Douglas A. Melton
author_facet	Edwin A. Rosado-Olivieri Kendall Anderson Jennifer H. Kenty Douglas A. Melton
author_sort	Edwin A. Rosado-Olivieri
title	YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
title_short	YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
title_full	YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
title_fullStr	YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
title_full_unstemmed	YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
title_sort	yap inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6daa58996f78488b8379255d83f5ea05
work_keys_str_mv	AT edwinarosadoolivieri yapinhibitionenhancesthedifferentiationoffunctionalstemcellderivedinsulinproducingbcells AT kendallanderson yapinhibitionenhancesthedifferentiationoffunctionalstemcellderivedinsulinproducingbcells AT jenniferhkenty yapinhibitionenhancesthedifferentiationoffunctionalstemcellderivedinsulinproducingbcells AT douglasamelton yapinhibitionenhancesthedifferentiationoffunctionalstemcellderivedinsulinproducingbcells
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YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

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