Risk Factors of Uterine Leiomyoma in Women of Reproductive Ages

BACKGROUND AND OBJECTIVE: Uterine leiomyoma is the most common benign pelvic tumors with an unknown etiology. There are contradictory results about risk factors of uterine leiomyoma which affiliated to genetic or hormonal theories, in different studies. The objective of this study is assessment of r...

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Autores principales:	SH Sharami, Z Zahiri, M Ghanaie
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	uterine fibroma risk factor oral contraceptives Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6dab209dd36d43b2beb6a7b1c0dd2086
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spelling	oai:doaj.org-article:6dab209dd36d43b2beb6a7b1c0dd20862021-11-10T09:03:00ZRisk Factors of Uterine Leiomyoma in Women of Reproductive Ages1561-41072251-7170https://doaj.org/article/6dab209dd36d43b2beb6a7b1c0dd20862009-10-01T00:00:00Zhttp://jbums.org/article-1-3259-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Uterine leiomyoma is the most common benign pelvic tumors with an unknown etiology. There are contradictory results about risk factors of uterine leiomyoma which affiliated to genetic or hormonal theories, in different studies. The objective of this study is assessment of risk factors of uterine leiomyoma in patients who referred for pelvic sonography in comparision to control group.METHODS: A case-control study was performed on 990 patients referring to Rasht Alzahra hospital in 2007 who undergoing sonography evaluation for abnormal bleeding or pelvic pain and for other reasons unrelated to abnormal bleeding. Patients were similar as parity and age. Patients based on sonography and uterine fibroma observation was divided into case and control groups. Considerable variables were demographic data, familial history leiomyoma, reproductive history and menstrual characteristics, body mass index, methods for contraception. Data were gathered by forms and face interview and then compared and assessed.FINDINGS: Of 990 patients, 482 subjects were cases and 508 subjects were controls. Premature menarche was reported in 69 cases (14.4%) and 48 control (9.4%), respectively. There were positive relationship between age of menarche 8-10 years old and increased risk of uterine leiomyoma (OR= 66%, 95% CI: 0.13-1.82), familial history of uterine leiomyoma (OR= 2.64, 95% CI=1.79-3.90), body mass index greater than 25 (OR=6.05, 95% CI: 4.18-8.75, menstrual characteristics and risk of uterine leiomyoma. There was an inverse relationship between use of oral contraceptive pills for pregnancy prevention and risk of uterine leiomyoma that was a protective effect. (OR=0.4 95% CI: 0.23-0.72)CONCLUSION: These results showed that uterine leiomyoma has a correlation with age of menarche, obesity, familial history of fibroma and inverse relationship with use of OCP. Prevention of overweight, use of oral contraceptive pills especially in high risk patients can be considered as the ways for prevention of uterine leiomyoma.SH Sharami,Z Zahiri,M GhanaieBabol University of Medical Sciencesarticleuterine fibromarisk factororal contraceptivesMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 11, Iss 4, Pp 54-61 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	uterine fibroma risk factor oral contraceptives Medicine R Medicine (General) R5-920
spellingShingle	uterine fibroma risk factor oral contraceptives Medicine R Medicine (General) R5-920 SH Sharami, Z Zahiri, M Ghanaie Risk Factors of Uterine Leiomyoma in Women of Reproductive Ages
description	BACKGROUND AND OBJECTIVE: Uterine leiomyoma is the most common benign pelvic tumors with an unknown etiology. There are contradictory results about risk factors of uterine leiomyoma which affiliated to genetic or hormonal theories, in different studies. The objective of this study is assessment of risk factors of uterine leiomyoma in patients who referred for pelvic sonography in comparision to control group.METHODS: A case-control study was performed on 990 patients referring to Rasht Alzahra hospital in 2007 who undergoing sonography evaluation for abnormal bleeding or pelvic pain and for other reasons unrelated to abnormal bleeding. Patients were similar as parity and age. Patients based on sonography and uterine fibroma observation was divided into case and control groups. Considerable variables were demographic data, familial history leiomyoma, reproductive history and menstrual characteristics, body mass index, methods for contraception. Data were gathered by forms and face interview and then compared and assessed.FINDINGS: Of 990 patients, 482 subjects were cases and 508 subjects were controls. Premature menarche was reported in 69 cases (14.4%) and 48 control (9.4%), respectively. There were positive relationship between age of menarche 8-10 years old and increased risk of uterine leiomyoma (OR= 66%, 95% CI: 0.13-1.82), familial history of uterine leiomyoma (OR= 2.64, 95% CI=1.79-3.90), body mass index greater than 25 (OR=6.05, 95% CI: 4.18-8.75, menstrual characteristics and risk of uterine leiomyoma. There was an inverse relationship between use of oral contraceptive pills for pregnancy prevention and risk of uterine leiomyoma that was a protective effect. (OR=0.4 95% CI: 0.23-0.72)CONCLUSION: These results showed that uterine leiomyoma has a correlation with age of menarche, obesity, familial history of fibroma and inverse relationship with use of OCP. Prevention of overweight, use of oral contraceptive pills especially in high risk patients can be considered as the ways for prevention of uterine leiomyoma.
format	article
author	SH Sharami, Z Zahiri, M Ghanaie
author_facet	SH Sharami, Z Zahiri, M Ghanaie
author_sort	SH Sharami,
title	Risk Factors of Uterine Leiomyoma in Women of Reproductive Ages
title_short	Risk Factors of Uterine Leiomyoma in Women of Reproductive Ages
title_full	Risk Factors of Uterine Leiomyoma in Women of Reproductive Ages
title_fullStr	Risk Factors of Uterine Leiomyoma in Women of Reproductive Ages
title_full_unstemmed	Risk Factors of Uterine Leiomyoma in Women of Reproductive Ages
title_sort	risk factors of uterine leiomyoma in women of reproductive ages
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/6dab209dd36d43b2beb6a7b1c0dd2086
work_keys_str_mv	AT shsharami riskfactorsofuterineleiomyomainwomenofreproductiveages AT zzahiri riskfactorsofuterineleiomyomainwomenofreproductiveages AT mghanaie riskfactorsofuterineleiomyomainwomenofreproductiveages
_version_	1718440294600409088

Risk Factors of Uterine Leiomyoma in Women of Reproductive Ages

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