Differential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice

Tobacco smoking increases the risk of metabolic disorders due to the combination of harmful chemicals, whereas pure nicotine can improve glucose tolerance. E-cigarette vapour contains nicotine and some of the harmful chemicals found in cigarette smoke at lower levels. To investigate how e-vapour aff...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hui Chen, Gerard Li, Yik Lung Chan, Hui Emma Zhang, Mark D. Gorrell, Carol A. Pollock, Sonia Saad, Brian G. Oliver
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	liver abdominal obesity free fatty acid triglycerides glucose tolerance Physiology QP1-981
Acceso en línea:	https://doaj.org/article/6daccfcfd4374bfc99055b30083d175c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6daccfcfd4374bfc99055b30083d175c
record_format	dspace
spelling	oai:doaj.org-article:6daccfcfd4374bfc99055b30083d175c2021-11-04T06:20:37ZDifferential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice1664-042X10.3389/fphys.2021.755124https://doaj.org/article/6daccfcfd4374bfc99055b30083d175c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.755124/fullhttps://doaj.org/toc/1664-042XTobacco smoking increases the risk of metabolic disorders due to the combination of harmful chemicals, whereas pure nicotine can improve glucose tolerance. E-cigarette vapour contains nicotine and some of the harmful chemicals found in cigarette smoke at lower levels. To investigate how e-vapour affects metabolic profiles, male Balb/c mice were exposed to a high-fat diet (HFD, 43% fat, 20kJ/g) for 16weeks, and e-vapour in the last 6weeks. HFD alone doubled fat mass and caused dyslipidaemia and glucose intolerance. E-vapour reduced fat mass in HFD-fed mice; only nicotine-containing e-vapour improved glucose tolerance. In chow-fed mice, e-vapour increased lipid content in both blood and liver. Changes in liver metabolic markers may be adaptive responses rather than causal. Future studies can investigate how e-vapour differentially affects metabolic profiles with different diets.Hui ChenGerard LiYik Lung ChanHui Emma ZhangMark D. GorrellCarol A. PollockSonia SaadBrian G. OliverBrian G. OliverFrontiers Media S.A.articleliverabdominal obesityfree fatty acidtriglyceridesglucose tolerancePhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liver abdominal obesity free fatty acid triglycerides glucose tolerance Physiology QP1-981
spellingShingle	liver abdominal obesity free fatty acid triglycerides glucose tolerance Physiology QP1-981 Hui Chen Gerard Li Yik Lung Chan Hui Emma Zhang Mark D. Gorrell Carol A. Pollock Sonia Saad Brian G. Oliver Brian G. Oliver Differential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice
description	Tobacco smoking increases the risk of metabolic disorders due to the combination of harmful chemicals, whereas pure nicotine can improve glucose tolerance. E-cigarette vapour contains nicotine and some of the harmful chemicals found in cigarette smoke at lower levels. To investigate how e-vapour affects metabolic profiles, male Balb/c mice were exposed to a high-fat diet (HFD, 43% fat, 20kJ/g) for 16weeks, and e-vapour in the last 6weeks. HFD alone doubled fat mass and caused dyslipidaemia and glucose intolerance. E-vapour reduced fat mass in HFD-fed mice; only nicotine-containing e-vapour improved glucose tolerance. In chow-fed mice, e-vapour increased lipid content in both blood and liver. Changes in liver metabolic markers may be adaptive responses rather than causal. Future studies can investigate how e-vapour differentially affects metabolic profiles with different diets.
format	article
author	Hui Chen Gerard Li Yik Lung Chan Hui Emma Zhang Mark D. Gorrell Carol A. Pollock Sonia Saad Brian G. Oliver Brian G. Oliver
author_facet	Hui Chen Gerard Li Yik Lung Chan Hui Emma Zhang Mark D. Gorrell Carol A. Pollock Sonia Saad Brian G. Oliver Brian G. Oliver
author_sort	Hui Chen
title	Differential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice
title_short	Differential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice
title_full	Differential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice
title_fullStr	Differential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice
title_full_unstemmed	Differential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice
title_sort	differential effects of ‘vaping’ on lipid and glucose profiles and liver metabolic markers in obese versus non-obese mice
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6daccfcfd4374bfc99055b30083d175c
work_keys_str_mv	AT huichen differentialeffectsofvapingonlipidandglucoseprofilesandlivermetabolicmarkersinobeseversusnonobesemice AT gerardli differentialeffectsofvapingonlipidandglucoseprofilesandlivermetabolicmarkersinobeseversusnonobesemice AT yiklungchan differentialeffectsofvapingonlipidandglucoseprofilesandlivermetabolicmarkersinobeseversusnonobesemice AT huiemmazhang differentialeffectsofvapingonlipidandglucoseprofilesandlivermetabolicmarkersinobeseversusnonobesemice AT markdgorrell differentialeffectsofvapingonlipidandglucoseprofilesandlivermetabolicmarkersinobeseversusnonobesemice AT carolapollock differentialeffectsofvapingonlipidandglucoseprofilesandlivermetabolicmarkersinobeseversusnonobesemice AT soniasaad differentialeffectsofvapingonlipidandglucoseprofilesandlivermetabolicmarkersinobeseversusnonobesemice AT briangoliver differentialeffectsofvapingonlipidandglucoseprofilesandlivermetabolicmarkersinobeseversusnonobesemice AT briangoliver differentialeffectsofvapingonlipidandglucoseprofilesandlivermetabolicmarkersinobeseversusnonobesemice
_version_	1718445094532546560

Differential Effects of ‘Vaping’ on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice

Ejemplares similares