Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers

Shuqin Ni, Lei Qiu, Guodong Zhang, Haiyan Zhou, Yong Han Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji’nan, Shandong, People’s Republic of China Purpose: Radiation and chemotherapy a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ni S, Qiu L, Zhang G, Zhou H, Han Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Combination chemotherapy B-cell lymphoma prodrug nanostructured lipid carriers targeted delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6daecd4c48334437a7169d5070a11719
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6daecd4c48334437a7169d5070a11719
record_format	dspace
spelling	oai:doaj.org-article:6daecd4c48334437a7169d5070a117192021-12-02T04:33:04ZLymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers1178-2013https://doaj.org/article/6daecd4c48334437a7169d5070a117192017-02-01T00:00:00Zhttps://www.dovepress.com/lymph-cancer-chemotherapy-delivery-of-doxorubicin-gemcitabine-prodrug--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shuqin Ni, Lei Qiu, Guodong Zhang, Haiyan Zhou, Yong Han Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji’nan, Shandong, People’s Republic of China Purpose: Radiation and chemotherapy are the most common course of treatment for B-cell lymphoma. Doxorubicin (DOX), gemcitabine (GEM), and vincristine (VCR) are the commonly used antilymphoma chemotherapeutic drugs. The aim of this study is to construct a novel drug delivery system for the combination delivery of the three drugs on lymphoma. Materials and methods: DOX–GEM prodrug was synthesized. Novel nanostructured lipid carriers (NLCs) containing DOX–GEM prodrug and VCR were prepared and used to treat B-cell lymphoma through in vivo treatment to a lymph cancer animal model. The systemic toxicity of the nanomedicine was also evaluated during the treatment. Results: DOX–GEM prodrug and VCR-loaded NLCs (DOX–GEM VCR NLCs) exhibited the highest antitumor effect in B-cell lymphoma cells and lymphoma animal xenografts when compared with the single drug-loaded NLCs and the drug solutions. Conclusion: It could be concluded that the highest antitumor effect can be achieved by the system due to the stable drug-loading capacity, attractive anticancer therapeutic effects, and reduced toxicities in human Burkitt’s lymphoma cell line and mice-bearing cancer model. The resulting DOX–GEM VCR NLCs could be an efficient antilymph cancer agent and could be developed further for the treatment of other tumors. Keywords: combination chemotherapy, B-cell lymphoma, prodrug, nanostructured lipid carriers, drug deliveryNi SQiu LZhang GZhou HHan YDove Medical PressarticleCombination chemotherapyB-cell lymphomaprodrugnanostructured lipid carrierstargeted deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1565-1576 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Combination chemotherapy B-cell lymphoma prodrug nanostructured lipid carriers targeted delivery Medicine (General) R5-920
spellingShingle	Combination chemotherapy B-cell lymphoma prodrug nanostructured lipid carriers targeted delivery Medicine (General) R5-920 Ni S Qiu L Zhang G Zhou H Han Y Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers
description	Shuqin Ni, Lei Qiu, Guodong Zhang, Haiyan Zhou, Yong Han Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji’nan, Shandong, People’s Republic of China Purpose: Radiation and chemotherapy are the most common course of treatment for B-cell lymphoma. Doxorubicin (DOX), gemcitabine (GEM), and vincristine (VCR) are the commonly used antilymphoma chemotherapeutic drugs. The aim of this study is to construct a novel drug delivery system for the combination delivery of the three drugs on lymphoma. Materials and methods: DOX–GEM prodrug was synthesized. Novel nanostructured lipid carriers (NLCs) containing DOX–GEM prodrug and VCR were prepared and used to treat B-cell lymphoma through in vivo treatment to a lymph cancer animal model. The systemic toxicity of the nanomedicine was also evaluated during the treatment. Results: DOX–GEM prodrug and VCR-loaded NLCs (DOX–GEM VCR NLCs) exhibited the highest antitumor effect in B-cell lymphoma cells and lymphoma animal xenografts when compared with the single drug-loaded NLCs and the drug solutions. Conclusion: It could be concluded that the highest antitumor effect can be achieved by the system due to the stable drug-loading capacity, attractive anticancer therapeutic effects, and reduced toxicities in human Burkitt’s lymphoma cell line and mice-bearing cancer model. The resulting DOX–GEM VCR NLCs could be an efficient antilymph cancer agent and could be developed further for the treatment of other tumors. Keywords: combination chemotherapy, B-cell lymphoma, prodrug, nanostructured lipid carriers, drug delivery
format	article
author	Ni S Qiu L Zhang G Zhou H Han Y
author_facet	Ni S Qiu L Zhang G Zhou H Han Y
author_sort	Ni S
title	Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers
title_short	Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers
title_full	Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers
title_fullStr	Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers
title_full_unstemmed	Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers
title_sort	lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/6daecd4c48334437a7169d5070a11719
work_keys_str_mv	AT nis lymphcancerchemotherapydeliveryofdoxorubicingemcitabineprodrugandvincristinebynanostructuredlipidcarriers AT qiul lymphcancerchemotherapydeliveryofdoxorubicingemcitabineprodrugandvincristinebynanostructuredlipidcarriers AT zhangg lymphcancerchemotherapydeliveryofdoxorubicingemcitabineprodrugandvincristinebynanostructuredlipidcarriers AT zhouh lymphcancerchemotherapydeliveryofdoxorubicingemcitabineprodrugandvincristinebynanostructuredlipidcarriers AT hany lymphcancerchemotherapydeliveryofdoxorubicingemcitabineprodrugandvincristinebynanostructuredlipidcarriers
_version_	1718401190929104896

Lymph cancer chemotherapy: delivery of doxorubicin-gemcitabine prodrug and vincristine by nanostructured lipid carriers

Ejemplares similares