Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study

Abstract Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN c...

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Autores principales:	Ashfaque A. Memon, Jan Sundquist, Anna Hedelius, Karolina Palmér, Xiao Wang, Kristina Sundquist
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6db1c99505054c34b6fb0a5c798a75c0
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spelling	oai:doaj.org-article:6db1c99505054c34b6fb0a5c798a75c02021-12-02T13:30:51ZAssociation of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study10.1038/s41598-021-84132-w2045-2322https://doaj.org/article/6db1c99505054c34b6fb0a5c798a75c02021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84132-whttps://doaj.org/toc/2045-2322Abstract Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of developing T2DM is not well-known. We quantified absolute mtDNA-CN in both prevalent and incident T2DM by well-optimized droplet digital PCR (ddPCR) method in a population-based follow-up study of middle aged (50–59 years) Swedish women (n = 2387). The median follow-up period was 17 years. Compared to those who were free of T2DM, mtDNA-CN was significantly lower in both prevalent T2DM and in women who developed T2DM during the follow-up period. Mitochondrial DNA-copy number was also associated with glucose intolerance, systolic blood pressure, smoking status and education. In multivariable Cox regression analysis, lower baseline mtDNA-CN was prospectively associated with a higher risk of T2DM, independent of age, BMI, education, smoking status and physical activity. Moreover, interaction term analysis showed that smoking increased the effect of low mtDNA-CN at baseline on the risk of incident T2DM. Mitochondrial DNA-copy number may be a risk factor of T2DM in women. The clinical usefulness of mtDNA-CN to predict the future risk of T2DM warrants further investigation.Ashfaque A. MemonJan SundquistAnna HedeliusKarolina PalmérXiao WangKristina SundquistNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ashfaque A. Memon Jan Sundquist Anna Hedelius Karolina Palmér Xiao Wang Kristina Sundquist Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study
description	Abstract Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of developing T2DM is not well-known. We quantified absolute mtDNA-CN in both prevalent and incident T2DM by well-optimized droplet digital PCR (ddPCR) method in a population-based follow-up study of middle aged (50–59 years) Swedish women (n = 2387). The median follow-up period was 17 years. Compared to those who were free of T2DM, mtDNA-CN was significantly lower in both prevalent T2DM and in women who developed T2DM during the follow-up period. Mitochondrial DNA-copy number was also associated with glucose intolerance, systolic blood pressure, smoking status and education. In multivariable Cox regression analysis, lower baseline mtDNA-CN was prospectively associated with a higher risk of T2DM, independent of age, BMI, education, smoking status and physical activity. Moreover, interaction term analysis showed that smoking increased the effect of low mtDNA-CN at baseline on the risk of incident T2DM. Mitochondrial DNA-copy number may be a risk factor of T2DM in women. The clinical usefulness of mtDNA-CN to predict the future risk of T2DM warrants further investigation.
format	article
author	Ashfaque A. Memon Jan Sundquist Anna Hedelius Karolina Palmér Xiao Wang Kristina Sundquist
author_facet	Ashfaque A. Memon Jan Sundquist Anna Hedelius Karolina Palmér Xiao Wang Kristina Sundquist
author_sort	Ashfaque A. Memon
title	Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study
title_short	Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study
title_full	Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study
title_fullStr	Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study
title_full_unstemmed	Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study
title_sort	association of mitochondrial dna copy number with prevalent and incident type 2 diabetes in women: a population-based follow-up study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6db1c99505054c34b6fb0a5c798a75c0
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Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study

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