Preventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice
Probiotics can prevent obesity and related metabolic complications. In our study, the protective effect and molecular mechanism of <i>Lactobacillus rhamnosus</i> JL1 (separated from the feces of healthy infants) on high-fat diet mice were investigated. After 10 weeks of dietary intervent...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/6dbb237ea5d24addb758bf1bddff64d7 |
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| Sumario: | Probiotics can prevent obesity and related metabolic complications. In our study, the protective effect and molecular mechanism of <i>Lactobacillus rhamnosus</i> JL1 (separated from the feces of healthy infants) on high-fat diet mice were investigated. After 10 weeks of dietary intervention with <i>L. rhamnosus</i> JL1 intervention, the body weight of the JL1 group (23.78 g) was significantly lower than that of the HFD group (26.59 g, <i>p</i> < 0.05) and the liver index was reduced. Serum biochemical analysis showed that the TC, TG and LDL-C contents of JL1 group mice were significantly decreased (<i>p</i> < 0.05). Histological images of the mice livers showed that the degree of lipid action and damage of hepatic cells were improved. <i>L. rhamnosus</i> JL1 activated the AMPK pathway, and reduced the gene expression of PPAR-γ, LXR-α and SREBP-1C. In addition, the protein expression of PPAR-γ and LXR-α were reduced. After dietary intervention with <i>L. rhamnosus</i> JL1, the concentration of acetic acid, propionic acid, and butyric acid were increased significantly, especially the concentration of butyric acid, which was 63.16% higher than that of the HFD group (<i>p</i> < 0.05). In conclusion, this study provided a theoretical reference for the development and application of probiotics derived from healthy infant feces in health products and functional foods. |
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