Preventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice

Probiotics can prevent obesity and related metabolic complications. In our study, the protective effect and molecular mechanism of <i>Lactobacillus rhamnosus</i> JL1 (separated from the feces of healthy infants) on high-fat diet mice were investigated. After 10 weeks of dietary intervent...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mo Yang, Jiapeng Zheng, Xinran Zong, Xinyan Yang, Yu Zhang, Chaoxin Man, Yujun Jiang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Lactobacillus rhamnosus</i> JL1 obesity probiotics signaling pathway Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6dbb237ea5d24addb758bf1bddff64d7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6dbb237ea5d24addb758bf1bddff64d7
record_format	dspace
spelling	oai:doaj.org-article:6dbb237ea5d24addb758bf1bddff64d72021-11-25T18:35:49ZPreventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice10.3390/nu131139892072-6643https://doaj.org/article/6dbb237ea5d24addb758bf1bddff64d72021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3989https://doaj.org/toc/2072-6643Probiotics can prevent obesity and related metabolic complications. In our study, the protective effect and molecular mechanism of <i>Lactobacillus rhamnosus</i> JL1 (separated from the feces of healthy infants) on high-fat diet mice were investigated. After 10 weeks of dietary intervention with <i>L. rhamnosus</i> JL1 intervention, the body weight of the JL1 group (23.78 g) was significantly lower than that of the HFD group (26.59 g, <i>p</i> < 0.05) and the liver index was reduced. Serum biochemical analysis showed that the TC, TG and LDL-C contents of JL1 group mice were significantly decreased (<i>p</i> < 0.05). Histological images of the mice livers showed that the degree of lipid action and damage of hepatic cells were improved. <i>L. rhamnosus</i> JL1 activated the AMPK pathway, and reduced the gene expression of PPAR-γ, LXR-α and SREBP-1C. In addition, the protein expression of PPAR-γ and LXR-α were reduced. After dietary intervention with <i>L. rhamnosus</i> JL1, the concentration of acetic acid, propionic acid, and butyric acid were increased significantly, especially the concentration of butyric acid, which was 63.16% higher than that of the HFD group (<i>p</i> < 0.05). In conclusion, this study provided a theoretical reference for the development and application of probiotics derived from healthy infant feces in health products and functional foods.Mo YangJiapeng ZhengXinran ZongXinyan YangYu ZhangChaoxin ManYujun JiangMDPI AGarticle<i>Lactobacillus rhamnosus</i> JL1obesityprobioticssignaling pathwayNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3989, p 3989 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Lactobacillus rhamnosus</i> JL1 obesity probiotics signaling pathway Nutrition. Foods and food supply TX341-641
spellingShingle	<i>Lactobacillus rhamnosus</i> JL1 obesity probiotics signaling pathway Nutrition. Foods and food supply TX341-641 Mo Yang Jiapeng Zheng Xinran Zong Xinyan Yang Yu Zhang Chaoxin Man Yujun Jiang Preventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice
description	Probiotics can prevent obesity and related metabolic complications. In our study, the protective effect and molecular mechanism of <i>Lactobacillus rhamnosus</i> JL1 (separated from the feces of healthy infants) on high-fat diet mice were investigated. After 10 weeks of dietary intervention with <i>L. rhamnosus</i> JL1 intervention, the body weight of the JL1 group (23.78 g) was significantly lower than that of the HFD group (26.59 g, <i>p</i> < 0.05) and the liver index was reduced. Serum biochemical analysis showed that the TC, TG and LDL-C contents of JL1 group mice were significantly decreased (<i>p</i> < 0.05). Histological images of the mice livers showed that the degree of lipid action and damage of hepatic cells were improved. <i>L. rhamnosus</i> JL1 activated the AMPK pathway, and reduced the gene expression of PPAR-γ, LXR-α and SREBP-1C. In addition, the protein expression of PPAR-γ and LXR-α were reduced. After dietary intervention with <i>L. rhamnosus</i> JL1, the concentration of acetic acid, propionic acid, and butyric acid were increased significantly, especially the concentration of butyric acid, which was 63.16% higher than that of the HFD group (<i>p</i> < 0.05). In conclusion, this study provided a theoretical reference for the development and application of probiotics derived from healthy infant feces in health products and functional foods.
format	article
author	Mo Yang Jiapeng Zheng Xinran Zong Xinyan Yang Yu Zhang Chaoxin Man Yujun Jiang
author_facet	Mo Yang Jiapeng Zheng Xinran Zong Xinyan Yang Yu Zhang Chaoxin Man Yujun Jiang
author_sort	Mo Yang
title	Preventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice
title_short	Preventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice
title_full	Preventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice
title_fullStr	Preventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice
title_full_unstemmed	Preventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice
title_sort	preventive effect and molecular mechanism of <i>lactobacillus rhamnosus</i> jl1 on food-borne obesity in mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6dbb237ea5d24addb758bf1bddff64d7
work_keys_str_mv	AT moyang preventiveeffectandmolecularmechanismofilactobacillusrhamnosusijl1onfoodborneobesityinmice AT jiapengzheng preventiveeffectandmolecularmechanismofilactobacillusrhamnosusijl1onfoodborneobesityinmice AT xinranzong preventiveeffectandmolecularmechanismofilactobacillusrhamnosusijl1onfoodborneobesityinmice AT xinyanyang preventiveeffectandmolecularmechanismofilactobacillusrhamnosusijl1onfoodborneobesityinmice AT yuzhang preventiveeffectandmolecularmechanismofilactobacillusrhamnosusijl1onfoodborneobesityinmice AT chaoxinman preventiveeffectandmolecularmechanismofilactobacillusrhamnosusijl1onfoodborneobesityinmice AT yujunjiang preventiveeffectandmolecularmechanismofilactobacillusrhamnosusijl1onfoodborneobesityinmice
_version_	1718410957943734272

Preventive Effect and Molecular Mechanism of <i>Lactobacillus rhamnosus</i> JL1 on Food-Borne Obesity in Mice

Ejemplares similares