In silico identification of potential inhibitors with higher potency than bumetanide targeting NKCC1: An important ion co-transporter to treat neurological disorders

Na + -K + -2Cl-cotransporter 1 (NKCC1) plays an important role in intracellular ionic homeostasis and cell volume regulation in the brain. Pathological activation of brain NKCC1 is associated with many brain disorders, including ischemic stroke, traumatic brain injury, epilepsy, neonatal seizure and...

Full description

Saved in:

Bibliographic Details
Main Authors:	Arpita Singha Roy, Md Sad Salabi Sawrav, Md Shahadat Hossain, Fatema Tuz Johura, Sk. Faisal Ahmed, Ithmam Hami, Md Kobirul Islam, Hasan Al Reza, Mohammad Iqbal H. Bhuiyan, Newaz Mohammed Bahadur, Md Mizanur Rahaman
Format:	article
Language:	EN
Published:	Elsevier 2021
Subjects:	NKCC1 CNS Compound library In silico Screening ADMET MD simulation Loop diuretics Computer applications to medicine. Medical informatics R858-859.7
Online Access:	https://doaj.org/article/6dbfcef71e5f44a6a6a914e6b7603b54
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!

In silico identification of potential inhibitors with higher potency than bumetanide targeting NKCC1: An important ion co-transporter to treat neurological disorders

Similar Items