Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study

Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central...

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Autores principales:	Maria Albanese, Stefano Di Girolamo, Lorenzo Silvani, Eleonora Ciaschi, Barbara Chiaramonte, Matteo Conti, Francesco Maria Passali, Battista Di Gioia, Nicola Biagio Mercuri, Arianna Di Stadio
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	migraine transient-evoked otoacoustic emissions distortion-product otoacoustic emissions cochlear damage hearing impairment olivocochlear system Medicine R
Acceso en línea:	https://doaj.org/article/6dc30fbe17294f2eb0acb7ea0347f8e3
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spelling	oai:doaj.org-article:6dc30fbe17294f2eb0acb7ea0347f8e32021-11-11T17:38:12ZDistortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study10.3390/jcm102150072077-0383https://doaj.org/article/6dc30fbe17294f2eb0acb7ea0347f8e32021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5007https://doaj.org/toc/2077-0383Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central etiology. However, increasing evidence also suggests a peripheral involvement of the inner ear in migraine. The aim of this study was to investigate the peripheral auditory pathway in migraineurs using otoacoustic emissions (OAEs), to detect alteration of cochlear functioning and possible relationship with disease severity. Sixty-two migraineurs and sixty matched controls were enrolled in the study and underwent a routine neuro-otolaryngology examination; self-administered questionnaires were used to evaluate subjective perception of hearing disability. DPOAE and their suppression were lower in migraineurs compared to controls and significantly related to the disease duration. Altered DPOAE exposed migraineurs to the risk of affecting by migraine without aura, of presenting with ocular and/or auditory symptoms during attack and of using more painkillers. Concomitant dopaminergic symptoms and/or allodynia such as the acute non-consumption of triptans were significant determinants of decreased contralateral suppression of DPOAE among migraineurs. This potential subclinical cochlear impairment in migraine detected by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a promising tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time.Maria AlbaneseStefano Di GirolamoLorenzo SilvaniEleonora CiaschiBarbara ChiaramonteMatteo ContiFrancesco Maria PassaliBattista Di GioiaNicola Biagio MercuriArianna Di StadioMDPI AGarticlemigrainetransient-evoked otoacoustic emissionsdistortion-product otoacoustic emissionscochlear damagehearing impairmentolivocochlear systemMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5007, p 5007 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	migraine transient-evoked otoacoustic emissions distortion-product otoacoustic emissions cochlear damage hearing impairment olivocochlear system Medicine R
spellingShingle	migraine transient-evoked otoacoustic emissions distortion-product otoacoustic emissions cochlear damage hearing impairment olivocochlear system Medicine R Maria Albanese Stefano Di Girolamo Lorenzo Silvani Eleonora Ciaschi Barbara Chiaramonte Matteo Conti Francesco Maria Passali Battista Di Gioia Nicola Biagio Mercuri Arianna Di Stadio Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
description	Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central etiology. However, increasing evidence also suggests a peripheral involvement of the inner ear in migraine. The aim of this study was to investigate the peripheral auditory pathway in migraineurs using otoacoustic emissions (OAEs), to detect alteration of cochlear functioning and possible relationship with disease severity. Sixty-two migraineurs and sixty matched controls were enrolled in the study and underwent a routine neuro-otolaryngology examination; self-administered questionnaires were used to evaluate subjective perception of hearing disability. DPOAE and their suppression were lower in migraineurs compared to controls and significantly related to the disease duration. Altered DPOAE exposed migraineurs to the risk of affecting by migraine without aura, of presenting with ocular and/or auditory symptoms during attack and of using more painkillers. Concomitant dopaminergic symptoms and/or allodynia such as the acute non-consumption of triptans were significant determinants of decreased contralateral suppression of DPOAE among migraineurs. This potential subclinical cochlear impairment in migraine detected by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a promising tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time.
format	article
author	Maria Albanese Stefano Di Girolamo Lorenzo Silvani Eleonora Ciaschi Barbara Chiaramonte Matteo Conti Francesco Maria Passali Battista Di Gioia Nicola Biagio Mercuri Arianna Di Stadio
author_facet	Maria Albanese Stefano Di Girolamo Lorenzo Silvani Eleonora Ciaschi Barbara Chiaramonte Matteo Conti Francesco Maria Passali Battista Di Gioia Nicola Biagio Mercuri Arianna Di Stadio
author_sort	Maria Albanese
title	Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_short	Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_full	Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_fullStr	Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_full_unstemmed	Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_sort	distortion product otoacoustic emissions and their suppression as predictors of peripheral auditory damage in migraine: a case-control study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6dc30fbe17294f2eb0acb7ea0347f8e3
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Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study

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