Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Ewing sarcoma is characterized by the fusion of EWSR1 and FLI1. Here, the authors show that EWSR1-FLI1 increases the activity of the developmental transcription factor SOX6, which promotes tumor growth but also increases sensitivity to oxidative stress.

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Autores principales:	Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M. L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L. B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino, Thomas G. P. Grünewald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6dc51a99a4e44ac186061ab97fa34c62
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spelling	oai:doaj.org-article:6dc51a99a4e44ac186061ab97fa34c622021-12-02T17:16:09ZOncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma10.1038/s41467-020-16244-22041-1723https://doaj.org/article/6dc51a99a4e44ac186061ab97fa34c622020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16244-2https://doaj.org/toc/2041-1723Ewing sarcoma is characterized by the fusion of EWSR1 and FLI1. Here, the authors show that EWSR1-FLI1 increases the activity of the developmental transcription factor SOX6, which promotes tumor growth but also increases sensitivity to oxidative stress.Aruna MarchettoShunya OhmuraMartin F. OrthMaximilian M. L. KnottMaria V. ColomboChiara ArrigoniVictor BardinetDavid SaucierFabienne S. WehweckJing LiStefanie SteinJulia S. GerkeMichaela C. BaldaufJulian MusaMarlene DallmayerLaura Romero-PérezTilman L. B. HöltingJames F. AmatrudaAndrea CossarizzaAnton G. HenssenThomas KirchnerMatteo MorettiFlorencia Cidre-AranazGiuseppina SanninoThomas G. P. GrünewaldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aruna Marchetto Shunya Ohmura Martin F. Orth Maximilian M. L. Knott Maria V. Colombo Chiara Arrigoni Victor Bardinet David Saucier Fabienne S. Wehweck Jing Li Stefanie Stein Julia S. Gerke Michaela C. Baldauf Julian Musa Marlene Dallmayer Laura Romero-Pérez Tilman L. B. Hölting James F. Amatruda Andrea Cossarizza Anton G. Henssen Thomas Kirchner Matteo Moretti Florencia Cidre-Aranaz Giuseppina Sannino Thomas G. P. Grünewald Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
description	Ewing sarcoma is characterized by the fusion of EWSR1 and FLI1. Here, the authors show that EWSR1-FLI1 increases the activity of the developmental transcription factor SOX6, which promotes tumor growth but also increases sensitivity to oxidative stress.
format	article
author	Aruna Marchetto Shunya Ohmura Martin F. Orth Maximilian M. L. Knott Maria V. Colombo Chiara Arrigoni Victor Bardinet David Saucier Fabienne S. Wehweck Jing Li Stefanie Stein Julia S. Gerke Michaela C. Baldauf Julian Musa Marlene Dallmayer Laura Romero-Pérez Tilman L. B. Hölting James F. Amatruda Andrea Cossarizza Anton G. Henssen Thomas Kirchner Matteo Moretti Florencia Cidre-Aranaz Giuseppina Sannino Thomas G. P. Grünewald
author_facet	Aruna Marchetto Shunya Ohmura Martin F. Orth Maximilian M. L. Knott Maria V. Colombo Chiara Arrigoni Victor Bardinet David Saucier Fabienne S. Wehweck Jing Li Stefanie Stein Julia S. Gerke Michaela C. Baldauf Julian Musa Marlene Dallmayer Laura Romero-Pérez Tilman L. B. Hölting James F. Amatruda Andrea Cossarizza Anton G. Henssen Thomas Kirchner Matteo Moretti Florencia Cidre-Aranaz Giuseppina Sannino Thomas G. P. Grünewald
author_sort	Aruna Marchetto
title	Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
title_short	Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
title_full	Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
title_fullStr	Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
title_full_unstemmed	Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
title_sort	oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in ewing sarcoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6dc51a99a4e44ac186061ab97fa34c62
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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

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