Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Ewing sarcoma is characterized by the fusion of EWSR1 and FLI1. Here, the authors show that EWSR1-FLI1 increases the activity of the developmental transcription factor SOX6, which promotes tumor growth but also increases sensitivity to oxidative stress.

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Main Authors: Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M. L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L. B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino, Thomas G. P. Grünewald
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/6dc51a99a4e44ac186061ab97fa34c62
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https://doaj.org/article/6dc51a99a4e44ac186061ab97fa34c62

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