Dissection of two routes to naïve pluripotency using different kinase inhibitors

Naïve pluripotency can be stabilized through different pharmacological approaches. Here, the authors profile temporal changes of protein phosphorylation, proteome and metabolome as mESCs transition to the naïve state in response to two pharmacological treatments, revealing general and treatment-spec...

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Autores principales:	Ana Martinez-Val, Cian J. Lynch, Isabel Calvo, Pilar Ximénez-Embún, Fernando Garcia, Eduardo Zarzuela, Manuel Serrano, Javier Munoz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6dc7983421e549f8afada656ff5c28a3
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spelling	oai:doaj.org-article:6dc7983421e549f8afada656ff5c28a32021-12-02T11:44:56ZDissection of two routes to naïve pluripotency using different kinase inhibitors10.1038/s41467-021-22181-52041-1723https://doaj.org/article/6dc7983421e549f8afada656ff5c28a32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22181-5https://doaj.org/toc/2041-1723Naïve pluripotency can be stabilized through different pharmacological approaches. Here, the authors profile temporal changes of protein phosphorylation, proteome and metabolome as mESCs transition to the naïve state in response to two pharmacological treatments, revealing general and treatment-specific processes.Ana Martinez-ValCian J. LynchIsabel CalvoPilar Ximénez-EmbúnFernando GarciaEduardo ZarzuelaManuel SerranoJavier MunozNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ana Martinez-Val Cian J. Lynch Isabel Calvo Pilar Ximénez-Embún Fernando Garcia Eduardo Zarzuela Manuel Serrano Javier Munoz Dissection of two routes to naïve pluripotency using different kinase inhibitors
description	Naïve pluripotency can be stabilized through different pharmacological approaches. Here, the authors profile temporal changes of protein phosphorylation, proteome and metabolome as mESCs transition to the naïve state in response to two pharmacological treatments, revealing general and treatment-specific processes.
format	article
author	Ana Martinez-Val Cian J. Lynch Isabel Calvo Pilar Ximénez-Embún Fernando Garcia Eduardo Zarzuela Manuel Serrano Javier Munoz
author_facet	Ana Martinez-Val Cian J. Lynch Isabel Calvo Pilar Ximénez-Embún Fernando Garcia Eduardo Zarzuela Manuel Serrano Javier Munoz
author_sort	Ana Martinez-Val
title	Dissection of two routes to naïve pluripotency using different kinase inhibitors
title_short	Dissection of two routes to naïve pluripotency using different kinase inhibitors
title_full	Dissection of two routes to naïve pluripotency using different kinase inhibitors
title_fullStr	Dissection of two routes to naïve pluripotency using different kinase inhibitors
title_full_unstemmed	Dissection of two routes to naïve pluripotency using different kinase inhibitors
title_sort	dissection of two routes to naïve pluripotency using different kinase inhibitors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6dc7983421e549f8afada656ff5c28a3
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Dissection of two routes to naïve pluripotency using different kinase inhibitors

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