Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition

The recent definition of an intermediate clinical phenotype of heart failure (HF) based on an ejection fraction (EF) of between 40% and 49%, namely HF with mid-range EF (HFmrEF), has fuelled investigations into the clinical profile and prognosis of this patient group. HFmrEF shares common clinical f...

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Autores principales:	Davide Margonato, Simone Mazzetti, Renata De Maria, Marco Gorini, Massimo Iacoviello, Aldo P Maggioni, Andrea Mortara
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2020
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/6dc9153648fd4728bf9feffc607665fb
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spelling	oai:doaj.org-article:6dc9153648fd4728bf9feffc607665fb2021-12-04T16:03:37ZHeart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition10.15420/cfr.2020.132057-75592057-7540https://doaj.org/article/6dc9153648fd4728bf9feffc607665fb2020-10-01T00:00:00Zhttps://www.cfrjournal.com/articles/heart-failure-with-mid-rangehttps://doaj.org/toc/2057-7540https://doaj.org/toc/2057-7559The recent definition of an intermediate clinical phenotype of heart failure (HF) based on an ejection fraction (EF) of between 40% and 49%, namely HF with mid-range EF (HFmrEF), has fuelled investigations into the clinical profile and prognosis of this patient group. HFmrEF shares common clinical features with other HF phenotypes, such as a high prevalence of ischaemic aetiology, as in HF with reduced EF (HFrEF), or hypertension and diabetes, as in HF with preserved EF (HFpEF), and benefits from the cornerstone drugs indicated for HFrEF. Among the HF phenotypes, HFmrEF is characterised by the highest rate of transition to either recovery or worsening of the severe systolic dysfunction profile that is the target of disease-modifying therapies, with opposite prognostic implications. This article focuses on the epidemiology, clinical characteristics and therapeutic approaches for HFmrEF, and discusses the major determinants of transition to HFpEF or HFrEF.Davide MargonatoSimone MazzettiRenata De MariaMarco GoriniMassimo IacovielloAldo P MaggioniAndrea MortaraRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiac Failure Review , Vol 6, Iss , Pp - (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Davide Margonato Simone Mazzetti Renata De Maria Marco Gorini Massimo Iacoviello Aldo P Maggioni Andrea Mortara Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition
description	The recent definition of an intermediate clinical phenotype of heart failure (HF) based on an ejection fraction (EF) of between 40% and 49%, namely HF with mid-range EF (HFmrEF), has fuelled investigations into the clinical profile and prognosis of this patient group. HFmrEF shares common clinical features with other HF phenotypes, such as a high prevalence of ischaemic aetiology, as in HF with reduced EF (HFrEF), or hypertension and diabetes, as in HF with preserved EF (HFpEF), and benefits from the cornerstone drugs indicated for HFrEF. Among the HF phenotypes, HFmrEF is characterised by the highest rate of transition to either recovery or worsening of the severe systolic dysfunction profile that is the target of disease-modifying therapies, with opposite prognostic implications. This article focuses on the epidemiology, clinical characteristics and therapeutic approaches for HFmrEF, and discusses the major determinants of transition to HFpEF or HFrEF.
format	article
author	Davide Margonato Simone Mazzetti Renata De Maria Marco Gorini Massimo Iacoviello Aldo P Maggioni Andrea Mortara
author_facet	Davide Margonato Simone Mazzetti Renata De Maria Marco Gorini Massimo Iacoviello Aldo P Maggioni Andrea Mortara
author_sort	Davide Margonato
title	Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition
title_short	Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition
title_full	Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition
title_fullStr	Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition
title_full_unstemmed	Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition
title_sort	heart failure with mid-range or recovered ejection fraction: differential determinants of transition
publisher	Radcliffe Medical Media
publishDate	2020
url	https://doaj.org/article/6dc9153648fd4728bf9feffc607665fb
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Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition

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