Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.

Growth hormone treatment strategies to achieve the goal include the titration of GH doses according to serum insulin-like growth factor I (IGF-I) concentrations. However, IGF-I levels do not always correlate well with the growth response. This study aims to identify the factors affecting the IGF-I c...

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Autores principales:	Ji Hyun Kim, Su Jin Kim, Jieun Lee, Choong Ho Shin, Ji-Young Seo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6dca2d4cc58b4aad816f030f43ceeb81
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spelling	oai:doaj.org-article:6dca2d4cc58b4aad816f030f43ceeb812021-12-02T20:05:01ZFactors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.1932-620310.1371/journal.pone.0252283https://doaj.org/article/6dca2d4cc58b4aad816f030f43ceeb812021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252283https://doaj.org/toc/1932-6203Growth hormone treatment strategies to achieve the goal include the titration of GH doses according to serum insulin-like growth factor I (IGF-I) concentrations. However, IGF-I levels do not always correlate well with the growth response. This study aims to identify the factors affecting the IGF-I concentration and identify the relationship between IGF-I and the treatment response. The data of prepubertal children treated with recombinant human GH for more than one year were obtained from the LG Growth Study (LGS) Database. This study includes patients with idiopathic growth hormone deficiency (IGHD), organic growth hormone deficiency (OGHD), or Turner syndrome (TS) or small for gestational age (SGA). Among 2,021 participants registered in LGS, 366 subjects were selected, 252 had IGHD, 16 had OGHD, 31 had TS, and 67 were SGA. In the IGHD and SGA groups, IGF-I levels had a positive correlation with weight SDS. There was no significant relationship between the pre-treatment IGF-I level and growth response. However, in the IGHD group, the growth response was significantly higher when the change in the IGF-I SDS value was 1 or more (p = 0.0013). Therefore, IGF-I concentrations should be used as an indicator to monitor the treatment compliance rather than for efficacy determination in Korean children of short stature with GH treatment.Ji Hyun KimSu Jin KimJieun LeeChoong Ho ShinJi-Young SeoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0252283 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji Hyun Kim Su Jin Kim Jieun Lee Choong Ho Shin Ji-Young Seo Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.
description	Growth hormone treatment strategies to achieve the goal include the titration of GH doses according to serum insulin-like growth factor I (IGF-I) concentrations. However, IGF-I levels do not always correlate well with the growth response. This study aims to identify the factors affecting the IGF-I concentration and identify the relationship between IGF-I and the treatment response. The data of prepubertal children treated with recombinant human GH for more than one year were obtained from the LG Growth Study (LGS) Database. This study includes patients with idiopathic growth hormone deficiency (IGHD), organic growth hormone deficiency (OGHD), or Turner syndrome (TS) or small for gestational age (SGA). Among 2,021 participants registered in LGS, 366 subjects were selected, 252 had IGHD, 16 had OGHD, 31 had TS, and 67 were SGA. In the IGHD and SGA groups, IGF-I levels had a positive correlation with weight SDS. There was no significant relationship between the pre-treatment IGF-I level and growth response. However, in the IGHD group, the growth response was significantly higher when the change in the IGF-I SDS value was 1 or more (p = 0.0013). Therefore, IGF-I concentrations should be used as an indicator to monitor the treatment compliance rather than for efficacy determination in Korean children of short stature with GH treatment.
format	article
author	Ji Hyun Kim Su Jin Kim Jieun Lee Choong Ho Shin Ji-Young Seo
author_facet	Ji Hyun Kim Su Jin Kim Jieun Lee Choong Ho Shin Ji-Young Seo
author_sort	Ji Hyun Kim
title	Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.
title_short	Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.
title_full	Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.
title_fullStr	Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.
title_full_unstemmed	Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.
title_sort	factors affecting igf-i level and correlation with growth response during growth hormone treatment in lg growth study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6dca2d4cc58b4aad816f030f43ceeb81
work_keys_str_mv	AT jihyunkim factorsaffectingigfilevelandcorrelationwithgrowthresponseduringgrowthhormonetreatmentinlggrowthstudy AT sujinkim factorsaffectingigfilevelandcorrelationwithgrowthresponseduringgrowthhormonetreatmentinlggrowthstudy AT jieunlee factorsaffectingigfilevelandcorrelationwithgrowthresponseduringgrowthhormonetreatmentinlggrowthstudy AT choonghoshin factorsaffectingigfilevelandcorrelationwithgrowthresponseduringgrowthhormonetreatmentinlggrowthstudy AT jiyoungseo factorsaffectingigfilevelandcorrelationwithgrowthresponseduringgrowthhormonetreatmentinlggrowthstudy
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Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study.

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