Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist

Abstract The complexity of the immune system creates challenges in exploring its importance and robustness. To date, there have been few techniques developed to manipulate individual components of the immune system in an in vivo environment. Here we show a light-based dendritic cell (DC) activation...

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Autores principales:	Keun Ah Ryu, Bethany McGonnigal, Troy Moore, Tawnya Kargupta, Rock J. Mancini, Aaron P. Esser-Kahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6dd0ef7d47564765af3665e173658a26
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spelling	oai:doaj.org-article:6dd0ef7d47564765af3665e173658a262021-12-02T15:05:42ZLight Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist10.1038/s41598-017-08520-x2045-2322https://doaj.org/article/6dd0ef7d47564765af3665e173658a262017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08520-xhttps://doaj.org/toc/2045-2322Abstract The complexity of the immune system creates challenges in exploring its importance and robustness. To date, there have been few techniques developed to manipulate individual components of the immune system in an in vivo environment. Here we show a light-based dendritic cell (DC) activation allowing spatial and temporal control of immune activation in vivo. Additionally, we show time dependent changes in RNA profiles of the draining lymph node, suggesting a change in cell profile following DC migration and indicating that the cells migrating have been activated towards antigen presentation.Keun Ah RyuBethany McGonnigalTroy MooreTawnya KarguptaRock J. ManciniAaron P. Esser-KahnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keun Ah Ryu Bethany McGonnigal Troy Moore Tawnya Kargupta Rock J. Mancini Aaron P. Esser-Kahn Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
description	Abstract The complexity of the immune system creates challenges in exploring its importance and robustness. To date, there have been few techniques developed to manipulate individual components of the immune system in an in vivo environment. Here we show a light-based dendritic cell (DC) activation allowing spatial and temporal control of immune activation in vivo. Additionally, we show time dependent changes in RNA profiles of the draining lymph node, suggesting a change in cell profile following DC migration and indicating that the cells migrating have been activated towards antigen presentation.
format	article
author	Keun Ah Ryu Bethany McGonnigal Troy Moore Tawnya Kargupta Rock J. Mancini Aaron P. Esser-Kahn
author_facet	Keun Ah Ryu Bethany McGonnigal Troy Moore Tawnya Kargupta Rock J. Mancini Aaron P. Esser-Kahn
author_sort	Keun Ah Ryu
title	Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
title_short	Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
title_full	Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
title_fullStr	Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
title_full_unstemmed	Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist
title_sort	light guided in-vivo activation of innate immune cells with photocaged tlr 2/6 agonist
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6dd0ef7d47564765af3665e173658a26
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Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist

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