SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors

Intracellular vesicle targeting is mediated by Rab GTPases that cooperate with phosphatidylinositides and SNARE proteins, which then facilitate membrane fusion. Here, the authors microinject artificial vesicles into HeLa cells and find that SNAREs play a more prominent role in targeting specificity...

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Autores principales: Seiichi Koike, Reinhard Jahn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6dd1376363bc458ab11ca7f21b655c37
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spelling oai:doaj.org-article:6dd1376363bc458ab11ca7f21b655c372021-12-02T14:39:17ZSNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors10.1038/s41467-019-09617-92041-1723https://doaj.org/article/6dd1376363bc458ab11ca7f21b655c372019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09617-9https://doaj.org/toc/2041-1723Intracellular vesicle targeting is mediated by Rab GTPases that cooperate with phosphatidylinositides and SNARE proteins, which then facilitate membrane fusion. Here, the authors microinject artificial vesicles into HeLa cells and find that SNAREs play a more prominent role in targeting specificity of trafficking vesicles than previously known.Seiichi KoikeReinhard JahnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Seiichi Koike
Reinhard Jahn
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors
description Intracellular vesicle targeting is mediated by Rab GTPases that cooperate with phosphatidylinositides and SNARE proteins, which then facilitate membrane fusion. Here, the authors microinject artificial vesicles into HeLa cells and find that SNAREs play a more prominent role in targeting specificity of trafficking vesicles than previously known.
format article
author Seiichi Koike
Reinhard Jahn
author_facet Seiichi Koike
Reinhard Jahn
author_sort Seiichi Koike
title SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors
title_short SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors
title_full SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors
title_fullStr SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors
title_full_unstemmed SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors
title_sort snares define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/6dd1376363bc458ab11ca7f21b655c37
work_keys_str_mv AT seiichikoike snaresdefinetargetingspecificityoftraffickingvesiclesbycombinatorialinteractionwithtetheringfactors
AT reinhardjahn snaresdefinetargetingspecificityoftraffickingvesiclesbycombinatorialinteractionwithtetheringfactors
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