SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors
Intracellular vesicle targeting is mediated by Rab GTPases that cooperate with phosphatidylinositides and SNARE proteins, which then facilitate membrane fusion. Here, the authors microinject artificial vesicles into HeLa cells and find that SNAREs play a more prominent role in targeting specificity...
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Nature Portfolio
2019
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oai:doaj.org-article:6dd1376363bc458ab11ca7f21b655c372021-12-02T14:39:17ZSNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors10.1038/s41467-019-09617-92041-1723https://doaj.org/article/6dd1376363bc458ab11ca7f21b655c372019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09617-9https://doaj.org/toc/2041-1723Intracellular vesicle targeting is mediated by Rab GTPases that cooperate with phosphatidylinositides and SNARE proteins, which then facilitate membrane fusion. Here, the authors microinject artificial vesicles into HeLa cells and find that SNAREs play a more prominent role in targeting specificity of trafficking vesicles than previously known.Seiichi KoikeReinhard JahnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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Science Q Seiichi Koike Reinhard Jahn SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors |
description |
Intracellular vesicle targeting is mediated by Rab GTPases that cooperate with phosphatidylinositides and SNARE proteins, which then facilitate membrane fusion. Here, the authors microinject artificial vesicles into HeLa cells and find that SNAREs play a more prominent role in targeting specificity of trafficking vesicles than previously known. |
format |
article |
author |
Seiichi Koike Reinhard Jahn |
author_facet |
Seiichi Koike Reinhard Jahn |
author_sort |
Seiichi Koike |
title |
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors |
title_short |
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors |
title_full |
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors |
title_fullStr |
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors |
title_full_unstemmed |
SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors |
title_sort |
snares define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/6dd1376363bc458ab11ca7f21b655c37 |
work_keys_str_mv |
AT seiichikoike snaresdefinetargetingspecificityoftraffickingvesiclesbycombinatorialinteractionwithtetheringfactors AT reinhardjahn snaresdefinetargetingspecificityoftraffickingvesiclesbycombinatorialinteractionwithtetheringfactors |
_version_ |
1718390660328849408 |