Modeling the transmission and control of Zika in Brazil

Abstract Zika virus, a reemerging mosquito-borne flavivirus, started spread across Central and Southern America and more recently to North America. The most serious impacted country is Brazil. Based on the transmission mechanism of the virus and assessment of the limited data on the reported suspect...

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Autores principales:	Liping Wang, Hongyong Zhao, Sergio Muniz Oliva, Huaiping Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6dd27c1f96cc4f75a8c6c3ec7390d9d3
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spelling	oai:doaj.org-article:6dd27c1f96cc4f75a8c6c3ec7390d9d32021-12-02T15:06:21ZModeling the transmission and control of Zika in Brazil10.1038/s41598-017-07264-y2045-2322https://doaj.org/article/6dd27c1f96cc4f75a8c6c3ec7390d9d32017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07264-yhttps://doaj.org/toc/2045-2322Abstract Zika virus, a reemerging mosquito-borne flavivirus, started spread across Central and Southern America and more recently to North America. The most serious impacted country is Brazil. Based on the transmission mechanism of the virus and assessment of the limited data on the reported suspected cases, we establish a dynamical model which allows us to estimate the basic reproduction number R 0 = 2.5020. The wild spreading of the virus make it a great challenge to public health to control and prevention of the virus. We formulate two control models to study the impact of releasing transgenosis mosquitoes (introducing bacterium Wolbachia into Aedes aegypti) on the transmission of Zika virus in Brazil. Our models and analysis suggest that simultaneously releasing Wolbachia-harboring female and male mosquitoes will achieve the target of population replacement, while releasing only Wolbachia-harboring male mosquitoes will suppress or even eradicate wild mosquitoes eventually. We conclude that only releasing male Wolbachia mosquitoes is a better strategy for control the spreading of Zika virus in Brazil.Liping WangHongyong ZhaoSergio Muniz OlivaHuaiping ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liping Wang Hongyong Zhao Sergio Muniz Oliva Huaiping Zhu Modeling the transmission and control of Zika in Brazil
description	Abstract Zika virus, a reemerging mosquito-borne flavivirus, started spread across Central and Southern America and more recently to North America. The most serious impacted country is Brazil. Based on the transmission mechanism of the virus and assessment of the limited data on the reported suspected cases, we establish a dynamical model which allows us to estimate the basic reproduction number R 0 = 2.5020. The wild spreading of the virus make it a great challenge to public health to control and prevention of the virus. We formulate two control models to study the impact of releasing transgenosis mosquitoes (introducing bacterium Wolbachia into Aedes aegypti) on the transmission of Zika virus in Brazil. Our models and analysis suggest that simultaneously releasing Wolbachia-harboring female and male mosquitoes will achieve the target of population replacement, while releasing only Wolbachia-harboring male mosquitoes will suppress or even eradicate wild mosquitoes eventually. We conclude that only releasing male Wolbachia mosquitoes is a better strategy for control the spreading of Zika virus in Brazil.
format	article
author	Liping Wang Hongyong Zhao Sergio Muniz Oliva Huaiping Zhu
author_facet	Liping Wang Hongyong Zhao Sergio Muniz Oliva Huaiping Zhu
author_sort	Liping Wang
title	Modeling the transmission and control of Zika in Brazil
title_short	Modeling the transmission and control of Zika in Brazil
title_full	Modeling the transmission and control of Zika in Brazil
title_fullStr	Modeling the transmission and control of Zika in Brazil
title_full_unstemmed	Modeling the transmission and control of Zika in Brazil
title_sort	modeling the transmission and control of zika in brazil
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6dd27c1f96cc4f75a8c6c3ec7390d9d3
work_keys_str_mv	AT lipingwang modelingthetransmissionandcontrolofzikainbrazil AT hongyongzhao modelingthetransmissionandcontrolofzikainbrazil AT sergiomunizoliva modelingthetransmissionandcontrolofzikainbrazil AT huaipingzhu modelingthetransmissionandcontrolofzikainbrazil
_version_	1718388517677039616

Modeling the transmission and control of Zika in Brazil

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