An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in he...

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Autores principales: Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T. S. Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W. H. Chan, Joanna H. Tong, Yue-Sun Cheung, Paul B. S. Lai, Hector K. S. Wang, Shun-Wa Tsang, King-Lau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, Ka-Fai To, Joseph J. Y. Sung, Grace L. H. Wong, Vincent W. S. Wong, Alfred S. L. Cheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6dd5d597aab145d5bf368e0227da0aaf
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spelling oai:doaj.org-article:6dd5d597aab145d5bf368e0227da0aaf2021-12-02T14:41:05ZAn inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma10.1038/s41467-018-07402-82041-1723https://doaj.org/article/6dd5d597aab145d5bf368e0227da0aaf2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07402-8https://doaj.org/toc/2041-1723Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming.Hanyong SunWeiqin YangYuan TianXuezhen ZengJingying ZhouMyth T. S. MokWenshu TangYu FengLiangliang XuAnthony W. H. ChanJoanna H. TongYue-Sun CheungPaul B. S. LaiHector K. S. WangShun-Wa TsangKing-Lau ChowMengying HuRihe LiuLeaf HuangBing YangPengyuan YangKa-Fai ToJoseph J. Y. SungGrace L. H. WongVincent W. S. WongAlfred S. L. ChengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hanyong Sun
Weiqin Yang
Yuan Tian
Xuezhen Zeng
Jingying Zhou
Myth T. S. Mok
Wenshu Tang
Yu Feng
Liangliang Xu
Anthony W. H. Chan
Joanna H. Tong
Yue-Sun Cheung
Paul B. S. Lai
Hector K. S. Wang
Shun-Wa Tsang
King-Lau Chow
Mengying Hu
Rihe Liu
Leaf Huang
Bing Yang
Pengyuan Yang
Ka-Fai To
Joseph J. Y. Sung
Grace L. H. Wong
Vincent W. S. Wong
Alfred S. L. Cheng
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
description Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming.
format article
author Hanyong Sun
Weiqin Yang
Yuan Tian
Xuezhen Zeng
Jingying Zhou
Myth T. S. Mok
Wenshu Tang
Yu Feng
Liangliang Xu
Anthony W. H. Chan
Joanna H. Tong
Yue-Sun Cheung
Paul B. S. Lai
Hector K. S. Wang
Shun-Wa Tsang
King-Lau Chow
Mengying Hu
Rihe Liu
Leaf Huang
Bing Yang
Pengyuan Yang
Ka-Fai To
Joseph J. Y. Sung
Grace L. H. Wong
Vincent W. S. Wong
Alfred S. L. Cheng
author_facet Hanyong Sun
Weiqin Yang
Yuan Tian
Xuezhen Zeng
Jingying Zhou
Myth T. S. Mok
Wenshu Tang
Yu Feng
Liangliang Xu
Anthony W. H. Chan
Joanna H. Tong
Yue-Sun Cheung
Paul B. S. Lai
Hector K. S. Wang
Shun-Wa Tsang
King-Lau Chow
Mengying Hu
Rihe Liu
Leaf Huang
Bing Yang
Pengyuan Yang
Ka-Fai To
Joseph J. Y. Sung
Grace L. H. Wong
Vincent W. S. Wong
Alfred S. L. Cheng
author_sort Hanyong Sun
title An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
title_short An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
title_full An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
title_fullStr An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
title_full_unstemmed An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
title_sort inflammatory-ccrk circuitry drives mtorc1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6dd5d597aab145d5bf368e0227da0aaf
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