Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation

Introduction: Transient hemodynamic instability is an inevitable outcome of laryngoscopy and intubation which can have serious effects in patients with COPD, heart disease and hypertension. Hemodynamic stability is one of the main goals of the anesthesiologist. This study was performed to compare t...

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Autores principales:	Ram Bhakta Koju, Y Dongol
Formato:	article
Lenguaje:	EN
Publicado:	Society of Surgeons of Nepal 2017
Materias:	Cardiovascular response Esmolol Hemodynamics Intubation Laryngoscopy Lidocaine Surgery RD1-811
Acceso en línea:	https://doaj.org/article/6dd85c63e3d4450981089c77be08f5c4
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spelling	oai:doaj.org-article:6dd85c63e3d4450981089c77be08f5c42021-12-05T19:16:21ZComparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation10.3126/jssn.v17i2.171441815-39842392-4772https://doaj.org/article/6dd85c63e3d4450981089c77be08f5c42017-04-01T00:00:00Zhttps://www.nepjol.info/index.php/JSSN/article/view/17144https://doaj.org/toc/1815-3984https://doaj.org/toc/2392-4772 Introduction: Transient hemodynamic instability is an inevitable outcome of laryngoscopy and intubation which can have serious effects in patients with COPD, heart disease and hypertension. Hemodynamic stability is one of the main goals of the anesthesiologist. This study was performed to compare the safety and effectiveness of lidocaine and esmolol in comparison to placebo-control group, in modifying the hemodynamic response to laryngoscopy and intubation. Methods: After approval of the study protocol by the institutional review board (IRB), written informed consent was obtained from each patient. It was a randomized placebo-controlled, double-blinded study. 75 patients of American Society of Anesthesiologists physical status I and II, scheduled for general surgery under GA, aged between 20-60 years were randomly allocated into three groups: placebo control group (n=25), lidocaine group (n=25) and esmolol group (n=25). Placebo group received 12 ml normal saline, lidocaine group received 1.5mg/kg lidocaine (total volume 12 ml) and esmolol group received 1.4mg/kg esmolol (total volume 12ml). Results: Following laryngoscopy and intubation, the increase in systolic blood pressure, diastolic blood pressure and heart rate were significantly lower (p < 0.05) in esmolol group compared to the lidocaine and placebo group but there was no statistical significance (p > 0.05) between control and lidocaine group. Conclusion: Esmolol 1.4 mg/kg IV was significantly more effective in controlling the hemodynamic response following laryngoscopy and intubation in comparison to lidocaine 1.5 mg/kg. Journal of Society of Surgeons of Nepal Vol. 17, No. 2, 2014, Page: 23-30 Ram Bhakta KojuY DongolSociety of Surgeons of NepalarticleCardiovascular responseEsmololHemodynamicsIntubationLaryngoscopyLidocaineSurgeryRD1-811ENJournal of Society of Surgeons of Nepal, Vol 17, Iss 2 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cardiovascular response Esmolol Hemodynamics Intubation Laryngoscopy Lidocaine Surgery RD1-811
spellingShingle	Cardiovascular response Esmolol Hemodynamics Intubation Laryngoscopy Lidocaine Surgery RD1-811 Ram Bhakta Koju Y Dongol Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation
description	Introduction: Transient hemodynamic instability is an inevitable outcome of laryngoscopy and intubation which can have serious effects in patients with COPD, heart disease and hypertension. Hemodynamic stability is one of the main goals of the anesthesiologist. This study was performed to compare the safety and effectiveness of lidocaine and esmolol in comparison to placebo-control group, in modifying the hemodynamic response to laryngoscopy and intubation. Methods: After approval of the study protocol by the institutional review board (IRB), written informed consent was obtained from each patient. It was a randomized placebo-controlled, double-blinded study. 75 patients of American Society of Anesthesiologists physical status I and II, scheduled for general surgery under GA, aged between 20-60 years were randomly allocated into three groups: placebo control group (n=25), lidocaine group (n=25) and esmolol group (n=25). Placebo group received 12 ml normal saline, lidocaine group received 1.5mg/kg lidocaine (total volume 12 ml) and esmolol group received 1.4mg/kg esmolol (total volume 12ml). Results: Following laryngoscopy and intubation, the increase in systolic blood pressure, diastolic blood pressure and heart rate were significantly lower (p < 0.05) in esmolol group compared to the lidocaine and placebo group but there was no statistical significance (p > 0.05) between control and lidocaine group. Conclusion: Esmolol 1.4 mg/kg IV was significantly more effective in controlling the hemodynamic response following laryngoscopy and intubation in comparison to lidocaine 1.5 mg/kg. Journal of Society of Surgeons of Nepal Vol. 17, No. 2, 2014, Page: 23-30
format	article
author	Ram Bhakta Koju Y Dongol
author_facet	Ram Bhakta Koju Y Dongol
author_sort	Ram Bhakta Koju
title	Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation
title_short	Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation
title_full	Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation
title_fullStr	Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation
title_full_unstemmed	Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation
title_sort	comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation
publisher	Society of Surgeons of Nepal
publishDate	2017
url	https://doaj.org/article/6dd85c63e3d4450981089c77be08f5c4
work_keys_str_mv	AT rambhaktakoju comparativeeffectsoflidocaineandesmololinattenuatingthehemodynamicresponsetolaryngoscopyandintubation AT ydongol comparativeeffectsoflidocaineandesmololinattenuatingthehemodynamicresponsetolaryngoscopyandintubation
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Comparative effects of lidocaine and esmolol in attenuating the hemodynamic response to laryngoscopy and intubation

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