Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

The mechanisms through which gut microbiota affect extramucosal tumors are poorly understood. Here the authors show that the gut microbiota promotes multiple myeloma by inducing differentiation and migration of Th17 cells in the bone marrow resulting also in increased recruitment of pro-tumorigenic...

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Autores principales:	Arianna Calcinotto, Arianna Brevi, Marta Chesi, Roberto Ferrarese, Laura Garcia Perez, Matteo Grioni, Shaji Kumar, Victoria M. Garbitt, Meaghen E. Sharik, Kimberly J. Henderson, Giovanni Tonon, Michio Tomura, Yoshihiro Miwa, Enric Esplugues, Richard A. Flavell, Samuel Huber, Filippo Canducci, Vincent S. Rajkumar, P. Leif Bergsagel, Matteo Bellone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6dd882c727de4bf2854877a2bb52782e
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spelling	oai:doaj.org-article:6dd882c727de4bf2854877a2bb52782e2021-12-02T14:40:32ZMicrobiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression10.1038/s41467-018-07305-82041-1723https://doaj.org/article/6dd882c727de4bf2854877a2bb52782e2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07305-8https://doaj.org/toc/2041-1723The mechanisms through which gut microbiota affect extramucosal tumors are poorly understood. Here the authors show that the gut microbiota promotes multiple myeloma by inducing differentiation and migration of Th17 cells in the bone marrow resulting also in increased recruitment of pro-tumorigenic eosinophils.Arianna CalcinottoArianna BreviMarta ChesiRoberto FerrareseLaura Garcia PerezMatteo GrioniShaji KumarVictoria M. GarbittMeaghen E. SharikKimberly J. HendersonGiovanni TononMichio TomuraYoshihiro MiwaEnric EspluguesRichard A. FlavellSamuel HuberFilippo CanducciVincent S. RajkumarP. Leif BergsagelMatteo BelloneNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arianna Calcinotto Arianna Brevi Marta Chesi Roberto Ferrarese Laura Garcia Perez Matteo Grioni Shaji Kumar Victoria M. Garbitt Meaghen E. Sharik Kimberly J. Henderson Giovanni Tonon Michio Tomura Yoshihiro Miwa Enric Esplugues Richard A. Flavell Samuel Huber Filippo Canducci Vincent S. Rajkumar P. Leif Bergsagel Matteo Bellone Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
description	The mechanisms through which gut microbiota affect extramucosal tumors are poorly understood. Here the authors show that the gut microbiota promotes multiple myeloma by inducing differentiation and migration of Th17 cells in the bone marrow resulting also in increased recruitment of pro-tumorigenic eosinophils.
format	article
author	Arianna Calcinotto Arianna Brevi Marta Chesi Roberto Ferrarese Laura Garcia Perez Matteo Grioni Shaji Kumar Victoria M. Garbitt Meaghen E. Sharik Kimberly J. Henderson Giovanni Tonon Michio Tomura Yoshihiro Miwa Enric Esplugues Richard A. Flavell Samuel Huber Filippo Canducci Vincent S. Rajkumar P. Leif Bergsagel Matteo Bellone
author_facet	Arianna Calcinotto Arianna Brevi Marta Chesi Roberto Ferrarese Laura Garcia Perez Matteo Grioni Shaji Kumar Victoria M. Garbitt Meaghen E. Sharik Kimberly J. Henderson Giovanni Tonon Michio Tomura Yoshihiro Miwa Enric Esplugues Richard A. Flavell Samuel Huber Filippo Canducci Vincent S. Rajkumar P. Leif Bergsagel Matteo Bellone
author_sort	Arianna Calcinotto
title	Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
title_short	Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
title_full	Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
title_fullStr	Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
title_full_unstemmed	Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
title_sort	microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6dd882c727de4bf2854877a2bb52782e
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Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

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