Iron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review

Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. IBD has been associated with numerous symptoms and complications, with the most common being iron deficiency anemia (IDA). Iron deficiency...

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Autores principales:	Dagmara Mahadea, Ewelina Adamczewska, Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Zawada, Piotr Eder, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	iron deficiency IBD dysbiosis dietary factors iron metabolism microbiota Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6dd90f2b1fcc427d8ab891d77e12762b
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spelling	oai:doaj.org-article:6dd90f2b1fcc427d8ab891d77e12762b2021-11-25T18:36:02ZIron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review10.3390/nu131140082072-6643https://doaj.org/article/6dd90f2b1fcc427d8ab891d77e12762b2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4008https://doaj.org/toc/2072-6643Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. IBD has been associated with numerous symptoms and complications, with the most common being iron deficiency anemia (IDA). Iron deficiency in IBD is caused by inadequate intake, malabsorption (including duodenal involvement and surgical removal), and chronic blood loss by mucosal ulcerations. Therefore, an appropriate diet should be enforced. Iron deficiency and iron supplementation have been associated with alterations to gut microbiota. IBD-associated anemia, in particular iron deficiency anemia, is associated with a significant decrease in quality of life and with clinical symptoms such as chronic fatigue, headaches and dizziness, reduced exercise tolerance, pale skin, nails, conjunctiva, and fainting. However, despite these numerous adverse symptoms, IDA remains undertreated. The European Crohn’s and Colitis Organisation (ECCO) guidelines state that patients should be monitored for anemia. Adequate treatment, whether oral or intravenous, should be implemented while taking into consideration C-reactive protein values (CRP), hemoglobin levels, and therapeutic response. It should be stressed that every case of anemia in IBD patients should be treated. Intravenous iron formulations, which are more superior compared to the oral form, should be used. There is a need to increase awareness and implementation of international guidelines on iron supplementation in patients with IBD.Dagmara MahadeaEwelina AdamczewskaAlicja Ewa RatajczakAnna Maria RychterAgnieszka ZawadaPiotr EderAgnieszka DobrowolskaIwona Krela-KaźmierczakMDPI AGarticleiron deficiencyIBDdysbiosisdietary factorsiron metabolismmicrobiotaNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4008, p 4008 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	iron deficiency IBD dysbiosis dietary factors iron metabolism microbiota Nutrition. Foods and food supply TX341-641
spellingShingle	iron deficiency IBD dysbiosis dietary factors iron metabolism microbiota Nutrition. Foods and food supply TX341-641 Dagmara Mahadea Ewelina Adamczewska Alicja Ewa Ratajczak Anna Maria Rychter Agnieszka Zawada Piotr Eder Agnieszka Dobrowolska Iwona Krela-Kaźmierczak Iron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review
description	Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. IBD has been associated with numerous symptoms and complications, with the most common being iron deficiency anemia (IDA). Iron deficiency in IBD is caused by inadequate intake, malabsorption (including duodenal involvement and surgical removal), and chronic blood loss by mucosal ulcerations. Therefore, an appropriate diet should be enforced. Iron deficiency and iron supplementation have been associated with alterations to gut microbiota. IBD-associated anemia, in particular iron deficiency anemia, is associated with a significant decrease in quality of life and with clinical symptoms such as chronic fatigue, headaches and dizziness, reduced exercise tolerance, pale skin, nails, conjunctiva, and fainting. However, despite these numerous adverse symptoms, IDA remains undertreated. The European Crohn’s and Colitis Organisation (ECCO) guidelines state that patients should be monitored for anemia. Adequate treatment, whether oral or intravenous, should be implemented while taking into consideration C-reactive protein values (CRP), hemoglobin levels, and therapeutic response. It should be stressed that every case of anemia in IBD patients should be treated. Intravenous iron formulations, which are more superior compared to the oral form, should be used. There is a need to increase awareness and implementation of international guidelines on iron supplementation in patients with IBD.
format	article
author	Dagmara Mahadea Ewelina Adamczewska Alicja Ewa Ratajczak Anna Maria Rychter Agnieszka Zawada Piotr Eder Agnieszka Dobrowolska Iwona Krela-Kaźmierczak
author_facet	Dagmara Mahadea Ewelina Adamczewska Alicja Ewa Ratajczak Anna Maria Rychter Agnieszka Zawada Piotr Eder Agnieszka Dobrowolska Iwona Krela-Kaźmierczak
author_sort	Dagmara Mahadea
title	Iron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review
title_short	Iron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review
title_full	Iron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review
title_fullStr	Iron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review
title_full_unstemmed	Iron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review
title_sort	iron deficiency anemia in inflammatory bowel diseases—a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6dd90f2b1fcc427d8ab891d77e12762b
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Iron Deficiency Anemia in Inflammatory Bowel Diseases—A Narrative Review

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