Heat Stress-Mediated Activation of Immune–Inflammatory Pathways

Physiological changes in animals exposed to elevated ambient temperature are characterized by the redistribution of blood toward the periphery to dissipate heat, with a consequent decline in blood flow and oxygen and nutrient supply to splanchnic tissues. Metabolic adaptations and gut dysfunction le...

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Autores principales:	Juan M. Cantet, Zhantao Yu, Agustín G. Ríus
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	heat stress heat shock protein inflammation intestine nutritional strategies Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6dd984e8240c4e468f8daa729350b561
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spelling	oai:doaj.org-article:6dd984e8240c4e468f8daa729350b5612021-11-25T16:21:57ZHeat Stress-Mediated Activation of Immune–Inflammatory Pathways10.3390/antibiotics101112852079-6382https://doaj.org/article/6dd984e8240c4e468f8daa729350b5612021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1285https://doaj.org/toc/2079-6382Physiological changes in animals exposed to elevated ambient temperature are characterized by the redistribution of blood toward the periphery to dissipate heat, with a consequent decline in blood flow and oxygen and nutrient supply to splanchnic tissues. Metabolic adaptations and gut dysfunction lead to oxidative stress, translocation of lumen contents, and release of proinflammatory mediators, activating a systemic inflammatory response. This review discusses the activation and development of the inflammatory response in heat-stressed models.Juan M. CantetZhantao YuAgustín G. RíusMDPI AGarticleheat stressheat shock proteininflammationintestinenutritional strategiesTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1285, p 1285 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heat stress heat shock protein inflammation intestine nutritional strategies Therapeutics. Pharmacology RM1-950
spellingShingle	heat stress heat shock protein inflammation intestine nutritional strategies Therapeutics. Pharmacology RM1-950 Juan M. Cantet Zhantao Yu Agustín G. Ríus Heat Stress-Mediated Activation of Immune–Inflammatory Pathways
description	Physiological changes in animals exposed to elevated ambient temperature are characterized by the redistribution of blood toward the periphery to dissipate heat, with a consequent decline in blood flow and oxygen and nutrient supply to splanchnic tissues. Metabolic adaptations and gut dysfunction lead to oxidative stress, translocation of lumen contents, and release of proinflammatory mediators, activating a systemic inflammatory response. This review discusses the activation and development of the inflammatory response in heat-stressed models.
format	article
author	Juan M. Cantet Zhantao Yu Agustín G. Ríus
author_facet	Juan M. Cantet Zhantao Yu Agustín G. Ríus
author_sort	Juan M. Cantet
title	Heat Stress-Mediated Activation of Immune–Inflammatory Pathways
title_short	Heat Stress-Mediated Activation of Immune–Inflammatory Pathways
title_full	Heat Stress-Mediated Activation of Immune–Inflammatory Pathways
title_fullStr	Heat Stress-Mediated Activation of Immune–Inflammatory Pathways
title_full_unstemmed	Heat Stress-Mediated Activation of Immune–Inflammatory Pathways
title_sort	heat stress-mediated activation of immune–inflammatory pathways
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6dd984e8240c4e468f8daa729350b561
work_keys_str_mv	AT juanmcantet heatstressmediatedactivationofimmuneinflammatorypathways AT zhantaoyu heatstressmediatedactivationofimmuneinflammatorypathways AT agustingrius heatstressmediatedactivationofimmuneinflammatorypathways
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Heat Stress-Mediated Activation of Immune–Inflammatory Pathways

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