Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease

Abstract Circulating microRNAs in the blood may provide diagnostic and prognostic information about canine neoplastic diseases, and their profiles may be conserved between human and canine species. We performed RT-qPCR to obtain the profiles of circulating plasma microRNA-214 and -126 in total 181 c...

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Autores principales:	Kazuki Heishima, Yukie Ichikawa, Kyoko Yoshida, Ryota Iwasaki, Hiroki Sakai, Takayuki Nakagawa, Yuiko Tanaka, Yuki Hoshino, Yasuhiko Okamura, Mami Murakami, Kohji Maruo, Yukihiro Akao, Takashi Mori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ddeb2ca6aaf435bb2f9d64d897c1666
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spelling	oai:doaj.org-article:6ddeb2ca6aaf435bb2f9d64d897c16662021-12-02T16:07:05ZCirculating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease10.1038/s41598-017-02607-12045-2322https://doaj.org/article/6ddeb2ca6aaf435bb2f9d64d897c16662017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02607-1https://doaj.org/toc/2045-2322Abstract Circulating microRNAs in the blood may provide diagnostic and prognostic information about canine neoplastic diseases, and their profiles may be conserved between human and canine species. We performed RT-qPCR to obtain the profiles of circulating plasma microRNA-214 and -126 in total 181 cases of canine neoplastic diseases and healthy controls. MicroRNA-214 levels were high in 2 epithelial tumours (thyroid and mammary carcinomas) and 4 non-epithelial tumours (osteosarcoma, histiocytic sarcoma, chondrosarcoma, and hemangiosarcoma). In contrast, microRNA-126 levels were high in 6 epithelial tumours (mammary, hepatocellular, squamous cell, thyroid, transitional cell carcinomas, and adenocarcinoma) and 4 non-epithelial tumours (osteosarcoma, mast cell tumour, melanoma, and hemangiosarcoma). The diagnostic potential of microRNA-214 was relatively high in sarcomas, whereas that of microR-126 was high in most types of the tumours. MicroRNA-214 and -126 were prognostic predictors in 2 groups (adenocarcinoma and non-epithelial tumours except for osteosarcoma) and 3 groups (epithelial tumours, adenocarcinoma, and melanoma), respectively. Additionally, the microRNA levels did not show a strong correlation with the other clinical parameters. In conclusion, circulating microRNA-214 and -126 have the potential to be diagnostic and prognostic biomarkers for canine neoplastic diseases. Furthermore, their profiles may be key references as well for exploring novel biomarkers for human cancers.Kazuki HeishimaYukie IchikawaKyoko YoshidaRyota IwasakiHiroki SakaiTakayuki NakagawaYuiko TanakaYuki HoshinoYasuhiko OkamuraMami MurakamiKohji MaruoYukihiro AkaoTakashi MoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazuki Heishima Yukie Ichikawa Kyoko Yoshida Ryota Iwasaki Hiroki Sakai Takayuki Nakagawa Yuiko Tanaka Yuki Hoshino Yasuhiko Okamura Mami Murakami Kohji Maruo Yukihiro Akao Takashi Mori Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease
description	Abstract Circulating microRNAs in the blood may provide diagnostic and prognostic information about canine neoplastic diseases, and their profiles may be conserved between human and canine species. We performed RT-qPCR to obtain the profiles of circulating plasma microRNA-214 and -126 in total 181 cases of canine neoplastic diseases and healthy controls. MicroRNA-214 levels were high in 2 epithelial tumours (thyroid and mammary carcinomas) and 4 non-epithelial tumours (osteosarcoma, histiocytic sarcoma, chondrosarcoma, and hemangiosarcoma). In contrast, microRNA-126 levels were high in 6 epithelial tumours (mammary, hepatocellular, squamous cell, thyroid, transitional cell carcinomas, and adenocarcinoma) and 4 non-epithelial tumours (osteosarcoma, mast cell tumour, melanoma, and hemangiosarcoma). The diagnostic potential of microRNA-214 was relatively high in sarcomas, whereas that of microR-126 was high in most types of the tumours. MicroRNA-214 and -126 were prognostic predictors in 2 groups (adenocarcinoma and non-epithelial tumours except for osteosarcoma) and 3 groups (epithelial tumours, adenocarcinoma, and melanoma), respectively. Additionally, the microRNA levels did not show a strong correlation with the other clinical parameters. In conclusion, circulating microRNA-214 and -126 have the potential to be diagnostic and prognostic biomarkers for canine neoplastic diseases. Furthermore, their profiles may be key references as well for exploring novel biomarkers for human cancers.
format	article
author	Kazuki Heishima Yukie Ichikawa Kyoko Yoshida Ryota Iwasaki Hiroki Sakai Takayuki Nakagawa Yuiko Tanaka Yuki Hoshino Yasuhiko Okamura Mami Murakami Kohji Maruo Yukihiro Akao Takashi Mori
author_facet	Kazuki Heishima Yukie Ichikawa Kyoko Yoshida Ryota Iwasaki Hiroki Sakai Takayuki Nakagawa Yuiko Tanaka Yuki Hoshino Yasuhiko Okamura Mami Murakami Kohji Maruo Yukihiro Akao Takashi Mori
author_sort	Kazuki Heishima
title	Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease
title_short	Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease
title_full	Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease
title_fullStr	Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease
title_full_unstemmed	Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease
title_sort	circulating microrna-214 and -126 as potential biomarkers for canine neoplastic disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6ddeb2ca6aaf435bb2f9d64d897c1666
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_version_	1718384722427510784

Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease

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