Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.

<h4>Background</h4>The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood.<h4>Methods</h4>We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elisabeth G W Huijskens, Johan Reimerink, Paul G H Mulder, Janko van Beek, Adam Meijer, Erwin de Bruin, Ingrid Friesema, Menno D de Jong, Guus F Rimmelzwaan, Marcel F Peeters, John W A Rossen, Marion Koopmans
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ddec03a52f74a5e9755c7e313dea3cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6ddec03a52f74a5e9755c7e313dea3cd
record_format	dspace
spelling	oai:doaj.org-article:6ddec03a52f74a5e9755c7e313dea3cd2021-11-18T08:00:00ZProfiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.1932-620310.1371/journal.pone.0054890https://doaj.org/article/6ddec03a52f74a5e9755c7e313dea3cd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23365683/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood.<h4>Methods</h4>We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria, Novartis), with and without a history of seasonal influenza vaccination. Antibodies were measured by hemagglutination inhibition (HI) assay for influenza A(H1N1)pdm09 and by protein microarray (PA) using the HA1 subunit for seven recent and historic H1, H2 and H3 influenza viruses, and three avian influenza viruses. Serum samples for the infection group were taken at the moment of collection of the diagnostic sample, 10 days and 30 days after onset of influenza symptoms. For the vaccination group, samples were drawn at baseline, 3 weeks after the first vaccination and 5 weeks after the second vaccination.<h4>Results</h4>We showed that subjects with a history of seasonal vaccination generally exhibited higher baseline titers for the various HA1 antigens than subjects without a seasonal vaccination history. Infection and pandemic influenza vaccination responses in persons with a history of seasonal vaccination were skewed towards historic antigens.<h4>Conclusions</h4>Seasonal vaccination is of significant influence on the antibody response to subsequent infection and vaccination, and further research is needed to understand the effect of annual vaccination on protective immunity.Elisabeth G W HuijskensJohan ReimerinkPaul G H MulderJanko van BeekAdam MeijerErwin de BruinIngrid FriesemaMenno D de JongGuus F RimmelzwaanMarcel F PeetersJohn W A RossenMarion KoopmansPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54890 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elisabeth G W Huijskens Johan Reimerink Paul G H Mulder Janko van Beek Adam Meijer Erwin de Bruin Ingrid Friesema Menno D de Jong Guus F Rimmelzwaan Marcel F Peeters John W A Rossen Marion Koopmans Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.
description	<h4>Background</h4>The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood.<h4>Methods</h4>We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria, Novartis), with and without a history of seasonal influenza vaccination. Antibodies were measured by hemagglutination inhibition (HI) assay for influenza A(H1N1)pdm09 and by protein microarray (PA) using the HA1 subunit for seven recent and historic H1, H2 and H3 influenza viruses, and three avian influenza viruses. Serum samples for the infection group were taken at the moment of collection of the diagnostic sample, 10 days and 30 days after onset of influenza symptoms. For the vaccination group, samples were drawn at baseline, 3 weeks after the first vaccination and 5 weeks after the second vaccination.<h4>Results</h4>We showed that subjects with a history of seasonal vaccination generally exhibited higher baseline titers for the various HA1 antigens than subjects without a seasonal vaccination history. Infection and pandemic influenza vaccination responses in persons with a history of seasonal vaccination were skewed towards historic antigens.<h4>Conclusions</h4>Seasonal vaccination is of significant influence on the antibody response to subsequent infection and vaccination, and further research is needed to understand the effect of annual vaccination on protective immunity.
format	article
author	Elisabeth G W Huijskens Johan Reimerink Paul G H Mulder Janko van Beek Adam Meijer Erwin de Bruin Ingrid Friesema Menno D de Jong Guus F Rimmelzwaan Marcel F Peeters John W A Rossen Marion Koopmans
author_facet	Elisabeth G W Huijskens Johan Reimerink Paul G H Mulder Janko van Beek Adam Meijer Erwin de Bruin Ingrid Friesema Menno D de Jong Guus F Rimmelzwaan Marcel F Peeters John W A Rossen Marion Koopmans
author_sort	Elisabeth G W Huijskens
title	Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.
title_short	Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.
title_full	Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.
title_fullStr	Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.
title_full_unstemmed	Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.
title_sort	profiling of humoral response to influenza a(h1n1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6ddec03a52f74a5e9755c7e313dea3cd
work_keys_str_mv	AT elisabethgwhuijskens profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT johanreimerink profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT paulghmulder profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT jankovanbeek profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT adammeijer profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT erwindebruin profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT ingridfriesema profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT mennoddejong profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT guusfrimmelzwaan profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT marcelfpeeters profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT johnwarossen profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination AT marionkoopmans profilingofhumoralresponsetoinfluenzaah1n1pdm09infectionandvaccinationmeasuredbyaproteinmicroarrayinpersonswithandwithouthistoryofseasonalvaccination
_version_	1718422671838937088

Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination.

Ejemplares similares