Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °C) in healthy young men with different physical fitness levels

Abstract We investigated the effects of single and repeated exposures to whole-body cryotherapy on biomarkers of bone remodeling and osteo-immune crosstalk: sclerostin, osteocalcin (OC), C-terminal cross-linked telopeptide of type I collagen (CTx-I), osteoprotegerin (OPG) and free soluble receptor a...

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Autores principales:	Anna Straburzyńska-Lupa, Tomasz Cisoń, Marta Gomarasca, Anna Babińska, Giuseppe Banfi, Giovanni Lombardi, Ewa Śliwicka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6de09f2abe27408baeb8816a3a391ae3
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spelling	oai:doaj.org-article:6de09f2abe27408baeb8816a3a391ae32021-12-02T15:08:22ZSclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °C) in healthy young men with different physical fitness levels10.1038/s41598-021-95492-82045-2322https://doaj.org/article/6de09f2abe27408baeb8816a3a391ae32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95492-8https://doaj.org/toc/2045-2322Abstract We investigated the effects of single and repeated exposures to whole-body cryotherapy on biomarkers of bone remodeling and osteo-immune crosstalk: sclerostin, osteocalcin (OC), C-terminal cross-linked telopeptide of type I collagen (CTx-I), osteoprotegerin (OPG) and free soluble receptor activator for nuclear factor κ B ligand (sRANKL). The study included 22 healthy males, grouped in high physical fitness level (HPhL) and low physical fitness level (LPhL), all undergone 10 consecutive sessions in a cryogenic chamber (− 110 °C). We observed a significant time-effect on sclerostin (p < 0.05), OC (p < 0.01), CTx-I (p < 0.001), OC/CTx-I (p < 0.05), and significant differences in sRANKL between the groups (p < 0.05) after the 1st cryostimulation; a significant time-effect on OC (p < 0.001) and OC/CTx-I (p < 0.001) after the 10th cryostimulation, and a significant time-effect on CTx-I (p < 0.001) and OC/CTx-I (p < 0.01) after 10 sessions of WBC. In conclusion, in young men, the first exposure to extreme cold induced significant changes in serum sclerostin. The changes in sRANKL, between groups, suggest that fitness level may modify the body's response to cold. The effects of the first stimulus and the whole session are not identical, probably due to the physiological development of habituation to cold.Anna Straburzyńska-LupaTomasz CisońMarta GomarascaAnna BabińskaGiuseppe BanfiGiovanni LombardiEwa ŚliwickaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Straburzyńska-Lupa Tomasz Cisoń Marta Gomarasca Anna Babińska Giuseppe Banfi Giovanni Lombardi Ewa Śliwicka Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °C) in healthy young men with different physical fitness levels
description	Abstract We investigated the effects of single and repeated exposures to whole-body cryotherapy on biomarkers of bone remodeling and osteo-immune crosstalk: sclerostin, osteocalcin (OC), C-terminal cross-linked telopeptide of type I collagen (CTx-I), osteoprotegerin (OPG) and free soluble receptor activator for nuclear factor κ B ligand (sRANKL). The study included 22 healthy males, grouped in high physical fitness level (HPhL) and low physical fitness level (LPhL), all undergone 10 consecutive sessions in a cryogenic chamber (− 110 °C). We observed a significant time-effect on sclerostin (p < 0.05), OC (p < 0.01), CTx-I (p < 0.001), OC/CTx-I (p < 0.05), and significant differences in sRANKL between the groups (p < 0.05) after the 1st cryostimulation; a significant time-effect on OC (p < 0.001) and OC/CTx-I (p < 0.001) after the 10th cryostimulation, and a significant time-effect on CTx-I (p < 0.001) and OC/CTx-I (p < 0.01) after 10 sessions of WBC. In conclusion, in young men, the first exposure to extreme cold induced significant changes in serum sclerostin. The changes in sRANKL, between groups, suggest that fitness level may modify the body's response to cold. The effects of the first stimulus and the whole session are not identical, probably due to the physiological development of habituation to cold.
format	article
author	Anna Straburzyńska-Lupa Tomasz Cisoń Marta Gomarasca Anna Babińska Giuseppe Banfi Giovanni Lombardi Ewa Śliwicka
author_facet	Anna Straburzyńska-Lupa Tomasz Cisoń Marta Gomarasca Anna Babińska Giuseppe Banfi Giovanni Lombardi Ewa Śliwicka
author_sort	Anna Straburzyńska-Lupa
title	Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °C) in healthy young men with different physical fitness levels
title_short	Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °C) in healthy young men with different physical fitness levels
title_full	Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °C) in healthy young men with different physical fitness levels
title_fullStr	Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °C) in healthy young men with different physical fitness levels
title_full_unstemmed	Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °C) in healthy young men with different physical fitness levels
title_sort	sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °c) in healthy young men with different physical fitness levels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6de09f2abe27408baeb8816a3a391ae3
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Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (− 110 °C) in healthy young men with different physical fitness levels

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