Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions

Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions

Focal adhesions (FAs) initiate chemical and mechanical signals involved in cell polarity, migration, proliferation and differentiation. Here, authors combine single protein tracking, super-resolution microscopy and functional assays, which allow correlating the molecular behaviour and 3D nanoscale l...

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Autores principales: Thomas Orré, Adrien Joly, Zeynep Karatas, Birgit Kastberger, Clément Cabriel, Ralph T. Böttcher, Sandrine Lévêque-Fort, Jean-Baptiste Sibarita, Reinhard Fässler, Bernhard Wehrle-Haller, Olivier Rossier, Grégory Giannone
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6de17fc1d26942499cf5255b08893432
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spelling oai:doaj.org-article:6de17fc1d26942499cf5255b088934322021-12-02T14:49:22ZMolecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions10.1038/s41467-021-23372-w2041-1723https://doaj.org/article/6de17fc1d26942499cf5255b088934322021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23372-whttps://doaj.org/toc/2041-1723Focal adhesions (FAs) initiate chemical and mechanical signals involved in cell polarity, migration, proliferation and differentiation. Here, authors combine single protein tracking, super-resolution microscopy and functional assays, which allow correlating the molecular behaviour and 3D nanoscale localization of kindlin with its function in integrin activation inside FAs.Thomas OrréAdrien JolyZeynep KaratasBirgit KastbergerClément CabrielRalph T. BöttcherSandrine Lévêque-FortJean-Baptiste SibaritaReinhard FässlerBernhard Wehrle-HallerOlivier RossierGrégory GiannoneNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Thomas Orré
Adrien Joly
Zeynep Karatas
Birgit Kastberger
Clément Cabriel
Ralph T. Böttcher
Sandrine Lévêque-Fort
Jean-Baptiste Sibarita
Reinhard Fässler
Bernhard Wehrle-Haller
Olivier Rossier
Grégory Giannone
Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
description Focal adhesions (FAs) initiate chemical and mechanical signals involved in cell polarity, migration, proliferation and differentiation. Here, authors combine single protein tracking, super-resolution microscopy and functional assays, which allow correlating the molecular behaviour and 3D nanoscale localization of kindlin with its function in integrin activation inside FAs.
format article
author Thomas Orré
Adrien Joly
Zeynep Karatas
Birgit Kastberger
Clément Cabriel
Ralph T. Böttcher
Sandrine Lévêque-Fort
Jean-Baptiste Sibarita
Reinhard Fässler
Bernhard Wehrle-Haller
Olivier Rossier
Grégory Giannone
author_facet Thomas Orré
Adrien Joly
Zeynep Karatas
Birgit Kastberger
Clément Cabriel
Ralph T. Böttcher
Sandrine Lévêque-Fort
Jean-Baptiste Sibarita
Reinhard Fässler
Bernhard Wehrle-Haller
Olivier Rossier
Grégory Giannone
author_sort Thomas Orré
title Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
title_short Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
title_full Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
title_fullStr Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
title_full_unstemmed Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
title_sort molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/6de17fc1d26942499cf5255b08893432
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