RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes

Alberto Mavilio,1 Dario Sisto,2 Paolo Ferreri,2 Rosanna Dammacco,2 Giovanni Alessio21Social Health District, Glaucoma Center, Azienda Sanitaria Locale, Brindisi, Italy; 2Department of Neurosciences, Institute of Ophthalmology, University of Bari, Bari, ItalyPurpose: To evaluate reliability of steady...

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Autores principales:	Mavilio A, Sisto D, Ferreri P, Dammacco R, Alessio G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	glaucoma pattern electroretinogram steady-state perg re-perg myopia Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6de268816eb54a648fb5969ad407b75e
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spelling	oai:doaj.org-article:6de268816eb54a648fb5969ad407b75e2021-12-02T03:31:56ZRE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes1177-5483https://doaj.org/article/6de268816eb54a648fb5969ad407b75e2019-07-01T00:00:00Zhttps://www.dovepress.com/re-perg-a-new-paradigm-for-glaucoma-diagnosis-in-myopic-eyes-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alberto Mavilio,1 Dario Sisto,2 Paolo Ferreri,2 Rosanna Dammacco,2 Giovanni Alessio21Social Health District, Glaucoma Center, Azienda Sanitaria Locale, Brindisi, Italy; 2Department of Neurosciences, Institute of Ophthalmology, University of Bari, Bari, ItalyPurpose: To evaluate reliability of steady-state pattern electroretinogram (ssPERG) phase variability in re-test (procedure called RE-PERG) in the presence of myopia, which is known to affect ssPERG amplitude, in glaucomatous patients (GP), normal controls (NC), and myopic patients (MY).Methods: The procedure was performed on 50 GP, 35 NC, and 19 MY. All subjects were examined with RE-PERG, spectral-domain coherence tomography (SD-OCT), and standard automated perimetry (SAP). Standard deviation of phase (ssPERG SDph) and mean amplitude value (ssPERG Amp) of second harmonic (2ndH) were correlated, by means of one-way ANOVA and Pearson correlation, with mean deviation (MD) and pattern standard deviation (PSD) assessed by SAP and retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness assessed by SD-OCT. Receiving operating characteristics were calculated in cohort populations with and without myopia.Results: GP showed significant differences from the control group for MD, PSD, RNFL, GCC, ssPERG Amp, and ssPERG SDph; GP also showed significant differences from the MY group for all the parameters except for ssPERG Amp, which is reduced in both groups. In GP group, ssPERG Amp showed a specificity of 82.1% (95% confidence interval [CI]I: 66.5–92.5). In MY group, ssPERG Amp was reduced in 58% of the patients. As a consequence of this, in GP and MY groups, considered as a whole, total specificity dropped to 70.69% (95% CI: 57.3–81.9). In the GP group, ssPERG SDph showed a specificity of 84.6% (95% CI: 69.5–91.1). In both GP and MY groups, considered as a whole, ssPERG SDph total specificity increased from 84.6% to 93.1% (95% CI: 83.3–98.1).Conclusion: Intrinsic phase variability of ssPERG is not influenced by myopia, even in the presence of fundus alterations.Keywords: glaucoma, pattern electroretinogram, steady-state, perg, re-perg, myopiaMavilio ASisto DFerreri PDammacco RAlessio GDove Medical Pressarticleglaucomapattern electroretinogramsteady-statepergre-pergmyopiaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1315-1322 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma pattern electroretinogram steady-state perg re-perg myopia Ophthalmology RE1-994
spellingShingle	glaucoma pattern electroretinogram steady-state perg re-perg myopia Ophthalmology RE1-994 Mavilio A Sisto D Ferreri P Dammacco R Alessio G RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes
description	Alberto Mavilio,1 Dario Sisto,2 Paolo Ferreri,2 Rosanna Dammacco,2 Giovanni Alessio21Social Health District, Glaucoma Center, Azienda Sanitaria Locale, Brindisi, Italy; 2Department of Neurosciences, Institute of Ophthalmology, University of Bari, Bari, ItalyPurpose: To evaluate reliability of steady-state pattern electroretinogram (ssPERG) phase variability in re-test (procedure called RE-PERG) in the presence of myopia, which is known to affect ssPERG amplitude, in glaucomatous patients (GP), normal controls (NC), and myopic patients (MY).Methods: The procedure was performed on 50 GP, 35 NC, and 19 MY. All subjects were examined with RE-PERG, spectral-domain coherence tomography (SD-OCT), and standard automated perimetry (SAP). Standard deviation of phase (ssPERG SDph) and mean amplitude value (ssPERG Amp) of second harmonic (2ndH) were correlated, by means of one-way ANOVA and Pearson correlation, with mean deviation (MD) and pattern standard deviation (PSD) assessed by SAP and retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness assessed by SD-OCT. Receiving operating characteristics were calculated in cohort populations with and without myopia.Results: GP showed significant differences from the control group for MD, PSD, RNFL, GCC, ssPERG Amp, and ssPERG SDph; GP also showed significant differences from the MY group for all the parameters except for ssPERG Amp, which is reduced in both groups. In GP group, ssPERG Amp showed a specificity of 82.1% (95% confidence interval [CI]I: 66.5–92.5). In MY group, ssPERG Amp was reduced in 58% of the patients. As a consequence of this, in GP and MY groups, considered as a whole, total specificity dropped to 70.69% (95% CI: 57.3–81.9). In the GP group, ssPERG SDph showed a specificity of 84.6% (95% CI: 69.5–91.1). In both GP and MY groups, considered as a whole, ssPERG SDph total specificity increased from 84.6% to 93.1% (95% CI: 83.3–98.1).Conclusion: Intrinsic phase variability of ssPERG is not influenced by myopia, even in the presence of fundus alterations.Keywords: glaucoma, pattern electroretinogram, steady-state, perg, re-perg, myopia
format	article
author	Mavilio A Sisto D Ferreri P Dammacco R Alessio G
author_facet	Mavilio A Sisto D Ferreri P Dammacco R Alessio G
author_sort	Mavilio A
title	RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes
title_short	RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes
title_full	RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes
title_fullStr	RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes
title_full_unstemmed	RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes
title_sort	re-perg, a new paradigm for glaucoma diagnosis, in myopic eyes
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/6de268816eb54a648fb5969ad407b75e
work_keys_str_mv	AT mavilioa reperganewparadigmforglaucomadiagnosisinmyopiceyes AT sistod reperganewparadigmforglaucomadiagnosisinmyopiceyes AT ferrerip reperganewparadigmforglaucomadiagnosisinmyopiceyes AT dammaccor reperganewparadigmforglaucomadiagnosisinmyopiceyes AT alessiog reperganewparadigmforglaucomadiagnosisinmyopiceyes
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RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes

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