An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis

Abstract Background The infection rate of congenital syphilis is gradually increasing, the clinical manifestations of some children with congenital syphilis are abnormal liver function, which is given the clinical diagnosis of syphilitic hepatitis. At present, there are few studies on the clinical f...

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Autores principales:	Hongling Yang, Huimin Zhang, Caiying Wang, Lin Pang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Syphilitic hepatitis Early congenital syphilis Clinical features Syphilis treatment Penicillin Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/6de2a8b8b7db43bebba49cc62062c90e
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spelling	oai:doaj.org-article:6de2a8b8b7db43bebba49cc62062c90e2021-11-14T12:33:22ZAn analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis10.1186/s12887-021-02932-51471-2431https://doaj.org/article/6de2a8b8b7db43bebba49cc62062c90e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-02932-5https://doaj.org/toc/1471-2431Abstract Background The infection rate of congenital syphilis is gradually increasing, the clinical manifestations of some children with congenital syphilis are abnormal liver function, which is given the clinical diagnosis of syphilitic hepatitis. At present, there are few studies on the clinical features of children with early congenital syphilis combined with syphilitic hepatitis, so we set out to do such a study. We compared the liver function indicators before and after the treatment of syphilis to find the clinical features that can provide guidance for clinical diagnosis and treatment. Methods This study collected clinical data on 51 children with early congenital syphilis combined with syphilitic hepatitis in Beijing Ditan Hospital, affiliated with Capital Medical University, between April 2014 and October 2019. We observed their age, gender, clinical symptoms, and physical symptoms, as well as the pregnancy and childbirth history of their mothers. We also compared the liver function indicators before and after the treatment of the syphilis and analyzed the children’s clinical features. Results The results of this study showed that the clinical manifestations in children with early congenital syphilis combined with syphilitic hepatitis were diverse. The most common clinical manifestation was anemia (56.9 %), followed by syphilitic rash (54.9 %), hands, feet, and whole-body peeling (35.3 %), and splenomegaly (29.4 %). Liver damage caused by a syphilis infection tends to result in elevated alanine aminotransferase, aspartate aminotransferase, and bilirubin, while albumin decreases. After the syphilis treatment, the liver function indexes were significantly improved compared with before treatment, and the difference was statistically significant (all p < 0.05). Conclusions A child with abnormal liver function, especially with anemia, skin rash, peeling, abdominal distension, and hepatosplenomegaly should be highly suspected of having a syphilis infection. Once the diagnosis is made, the appropriate standard penicillin treatment should be started as soon as possible to improve the condition and prognosis of the child.Hongling YangHuimin ZhangCaiying WangLin PangBMCarticleSyphilitic hepatitisEarly congenital syphilisClinical featuresSyphilis treatmentPenicillinPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Syphilitic hepatitis Early congenital syphilis Clinical features Syphilis treatment Penicillin Pediatrics RJ1-570
spellingShingle	Syphilitic hepatitis Early congenital syphilis Clinical features Syphilis treatment Penicillin Pediatrics RJ1-570 Hongling Yang Huimin Zhang Caiying Wang Lin Pang An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis
description	Abstract Background The infection rate of congenital syphilis is gradually increasing, the clinical manifestations of some children with congenital syphilis are abnormal liver function, which is given the clinical diagnosis of syphilitic hepatitis. At present, there are few studies on the clinical features of children with early congenital syphilis combined with syphilitic hepatitis, so we set out to do such a study. We compared the liver function indicators before and after the treatment of syphilis to find the clinical features that can provide guidance for clinical diagnosis and treatment. Methods This study collected clinical data on 51 children with early congenital syphilis combined with syphilitic hepatitis in Beijing Ditan Hospital, affiliated with Capital Medical University, between April 2014 and October 2019. We observed their age, gender, clinical symptoms, and physical symptoms, as well as the pregnancy and childbirth history of their mothers. We also compared the liver function indicators before and after the treatment of the syphilis and analyzed the children’s clinical features. Results The results of this study showed that the clinical manifestations in children with early congenital syphilis combined with syphilitic hepatitis were diverse. The most common clinical manifestation was anemia (56.9 %), followed by syphilitic rash (54.9 %), hands, feet, and whole-body peeling (35.3 %), and splenomegaly (29.4 %). Liver damage caused by a syphilis infection tends to result in elevated alanine aminotransferase, aspartate aminotransferase, and bilirubin, while albumin decreases. After the syphilis treatment, the liver function indexes were significantly improved compared with before treatment, and the difference was statistically significant (all p < 0.05). Conclusions A child with abnormal liver function, especially with anemia, skin rash, peeling, abdominal distension, and hepatosplenomegaly should be highly suspected of having a syphilis infection. Once the diagnosis is made, the appropriate standard penicillin treatment should be started as soon as possible to improve the condition and prognosis of the child.
format	article
author	Hongling Yang Huimin Zhang Caiying Wang Lin Pang
author_facet	Hongling Yang Huimin Zhang Caiying Wang Lin Pang
author_sort	Hongling Yang
title	An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis
title_short	An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis
title_full	An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis
title_fullStr	An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis
title_full_unstemmed	An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis
title_sort	analysis of the clinical features of children with early congenital syphilis and syphilitic hepatitis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6de2a8b8b7db43bebba49cc62062c90e
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An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis

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