Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan

Abstract The incidence of oral cavity squamous cell carcinoma (OSCC) is particularly high in South Asia. According to the National Comprehensive Cancer Network, OSCC can arise in several subsites. We investigated survival rates and the clinical and pathological characteristics of OSCC in different a...

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Autores principales:	Nan-Chin Lin, Su-I Hsien, Jui-Ting Hsu, Michael Y. C. Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6de2fc8a7f1d4112957fa3806c2534b8
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spelling	oai:doaj.org-article:6de2fc8a7f1d4112957fa3806c2534b82021-12-02T16:31:48ZImpact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan10.1038/s41598-021-95007-52045-2322https://doaj.org/article/6de2fc8a7f1d4112957fa3806c2534b82021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95007-5https://doaj.org/toc/2045-2322Abstract The incidence of oral cavity squamous cell carcinoma (OSCC) is particularly high in South Asia. According to the National Comprehensive Cancer Network, OSCC can arise in several subsites. We investigated survival rates and the clinical and pathological characteristics of OSCC in different anatomical subsites in the Taiwanese population. We retrospectively analyzed data for 3010 patients with OSCC treated at the Changhua Christian Hospital. Subsequently, we compared clinical and pathological features of OSCC in different subsites. Pathological T4 stage OSCCs occurred in the alveolar ridge and retromolar trigone in 56.4% and 43.7% of cases, respectively. More than 25% of patients with tongue OSCC and 23.4% of those with retromolar OSCC had lymph node metastasis. The prognosis was worst for hard palate OSCC (hazard ratio 1.848; p < 0.001) and alveolar ridge OSCC (hazard ratio 1.220; p = 0.017). Retromolar OSCC recurred most often and tongue OSCC second most often. The risk for cancer-related mortality was highest for hard palate OSCC, followed by alveolar ridge and retromolar OSCC. We found distinct differences in survival among the different subsites of OSCC. Our findings may also help prompt future investigations of OSCC in different subsites in Taiwanese patients.Nan-Chin LinSu-I HsienJui-Ting HsuMichael Y. C. ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nan-Chin Lin Su-I Hsien Jui-Ting Hsu Michael Y. C. Chen Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan
description	Abstract The incidence of oral cavity squamous cell carcinoma (OSCC) is particularly high in South Asia. According to the National Comprehensive Cancer Network, OSCC can arise in several subsites. We investigated survival rates and the clinical and pathological characteristics of OSCC in different anatomical subsites in the Taiwanese population. We retrospectively analyzed data for 3010 patients with OSCC treated at the Changhua Christian Hospital. Subsequently, we compared clinical and pathological features of OSCC in different subsites. Pathological T4 stage OSCCs occurred in the alveolar ridge and retromolar trigone in 56.4% and 43.7% of cases, respectively. More than 25% of patients with tongue OSCC and 23.4% of those with retromolar OSCC had lymph node metastasis. The prognosis was worst for hard palate OSCC (hazard ratio 1.848; p < 0.001) and alveolar ridge OSCC (hazard ratio 1.220; p = 0.017). Retromolar OSCC recurred most often and tongue OSCC second most often. The risk for cancer-related mortality was highest for hard palate OSCC, followed by alveolar ridge and retromolar OSCC. We found distinct differences in survival among the different subsites of OSCC. Our findings may also help prompt future investigations of OSCC in different subsites in Taiwanese patients.
format	article
author	Nan-Chin Lin Su-I Hsien Jui-Ting Hsu Michael Y. C. Chen
author_facet	Nan-Chin Lin Su-I Hsien Jui-Ting Hsu Michael Y. C. Chen
author_sort	Nan-Chin Lin
title	Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan
title_short	Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan
title_full	Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan
title_fullStr	Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan
title_full_unstemmed	Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan
title_sort	impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in taiwan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6de2fc8a7f1d4112957fa3806c2534b8
work_keys_str_mv	AT nanchinlin impactonpatientswithoralsquamouscellcarcinomaindifferentanatomicalsubsitesasinglecenterstudyintaiwan AT suihsien impactonpatientswithoralsquamouscellcarcinomaindifferentanatomicalsubsitesasinglecenterstudyintaiwan AT juitinghsu impactonpatientswithoralsquamouscellcarcinomaindifferentanatomicalsubsitesasinglecenterstudyintaiwan AT michaelycchen impactonpatientswithoralsquamouscellcarcinomaindifferentanatomicalsubsitesasinglecenterstudyintaiwan
_version_	1718383879105019904

Impact on patients with oral squamous cell carcinoma in different anatomical subsites: a single-center study in Taiwan

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