SARS-CoV-2 Infection and C-Section: A Prospective Observational Study

Pregnant women are particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In addition to unfavorable perinatal outcomes, there has been an increase in obstetric interventions. With this study, we aimed to clarify the reasons, using Robson’s classificati...

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Autores principales:	Eva Morán Antolín, José Román Broullón Molanes, María Luisa de la Cruz Conty, María Begoña Encinas Pardilla, María del Pilar Guadix Martín, José Antonio Sainz Bueno, Laura Forcén Acebal, Pilar Pintado Recarte, Ana Álvarez Bartolomé, Juan Pedro Martínez Cendán, Óscar Martínez-Pérez, on behalf of the Spanish Obstetric Emergency Group
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 pregnancy delivery C-section Robson’s ten group Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6de6369e3e6c4e20b90c8358118fd2b7
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spelling	oai:doaj.org-article:6de6369e3e6c4e20b90c8358118fd2b72021-11-25T19:14:38ZSARS-CoV-2 Infection and C-Section: A Prospective Observational Study10.3390/v131123301999-4915https://doaj.org/article/6de6369e3e6c4e20b90c8358118fd2b72021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2330https://doaj.org/toc/1999-4915Pregnant women are particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In addition to unfavorable perinatal outcomes, there has been an increase in obstetric interventions. With this study, we aimed to clarify the reasons, using Robson’s classification model, and risk factors for cesarean section (C-section) in SARS-CoV-2-infected mothers and their perinatal results. This was a prospective observational study that was carried out in 79 hospitals (Spanish Obstetric Emergency Group) with a cohort of 1704 SARS-CoV-2 PCR-positive pregnant women that were registered consecutively between 26 February and 5 November 2020. The data from 1248 pregnant women who delivered vaginally (vaginal + operative vaginal) was compared with those from 456 (26.8%) who underwent a C-section. C-section patients were older with higher rates of comorbidities, in vitro fertilization and multiple pregnancies (<i>p</i> < 0.05) compared with women who delivered vaginally. Moreover, C-section risk was associated with the presence of pneumonia (<i>p</i> < 0.001) and 41.1% of C-sections in patients with pneumonia were preterm (Robson’s 10th category). However, delivery care was similar between asymptomatic and mild–moderate symptomatic patients (<i>p</i> = 0.228) and their predisposing factors to C-section were the presence of uterine scarring (due to a previous C-section) and the induction of labor or programmed C-section for unspecified obstetric reasons. On the other hand, higher rates of hemorrhagic events, hypertensive disorders and thrombotic events were observed in the C-section group (<i>p</i> < 0.001 for all three outcomes), as well as for ICU admission. These findings suggest that this type of delivery was associated with the mother’s clinical conditions that required a rapid and early termination of pregnancy.Eva Morán AntolínJosé Román Broullón MolanesMaría Luisa de la Cruz ContyMaría Begoña Encinas PardillaMaría del Pilar Guadix MartínJosé Antonio Sainz BuenoLaura Forcén AcebalPilar Pintado RecarteAna Álvarez BartoloméJuan Pedro Martínez CendánÓscar Martínez-Pérezon behalf of the Spanish Obstetric Emergency GroupMDPI AGarticleSARS-CoV-2COVID-19pregnancydeliveryC-sectionRobson’s ten groupMicrobiologyQR1-502ENViruses, Vol 13, Iss 2330, p 2330 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 pregnancy delivery C-section Robson’s ten group Microbiology QR1-502
spellingShingle	SARS-CoV-2 COVID-19 pregnancy delivery C-section Robson’s ten group Microbiology QR1-502 Eva Morán Antolín José Román Broullón Molanes María Luisa de la Cruz Conty María Begoña Encinas Pardilla María del Pilar Guadix Martín José Antonio Sainz Bueno Laura Forcén Acebal Pilar Pintado Recarte Ana Álvarez Bartolomé Juan Pedro Martínez Cendán Óscar Martínez-Pérez on behalf of the Spanish Obstetric Emergency Group SARS-CoV-2 Infection and C-Section: A Prospective Observational Study
description	Pregnant women are particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. In addition to unfavorable perinatal outcomes, there has been an increase in obstetric interventions. With this study, we aimed to clarify the reasons, using Robson’s classification model, and risk factors for cesarean section (C-section) in SARS-CoV-2-infected mothers and their perinatal results. This was a prospective observational study that was carried out in 79 hospitals (Spanish Obstetric Emergency Group) with a cohort of 1704 SARS-CoV-2 PCR-positive pregnant women that were registered consecutively between 26 February and 5 November 2020. The data from 1248 pregnant women who delivered vaginally (vaginal + operative vaginal) was compared with those from 456 (26.8%) who underwent a C-section. C-section patients were older with higher rates of comorbidities, in vitro fertilization and multiple pregnancies (<i>p</i> < 0.05) compared with women who delivered vaginally. Moreover, C-section risk was associated with the presence of pneumonia (<i>p</i> < 0.001) and 41.1% of C-sections in patients with pneumonia were preterm (Robson’s 10th category). However, delivery care was similar between asymptomatic and mild–moderate symptomatic patients (<i>p</i> = 0.228) and their predisposing factors to C-section were the presence of uterine scarring (due to a previous C-section) and the induction of labor or programmed C-section for unspecified obstetric reasons. On the other hand, higher rates of hemorrhagic events, hypertensive disorders and thrombotic events were observed in the C-section group (<i>p</i> < 0.001 for all three outcomes), as well as for ICU admission. These findings suggest that this type of delivery was associated with the mother’s clinical conditions that required a rapid and early termination of pregnancy.
format	article
author	Eva Morán Antolín José Román Broullón Molanes María Luisa de la Cruz Conty María Begoña Encinas Pardilla María del Pilar Guadix Martín José Antonio Sainz Bueno Laura Forcén Acebal Pilar Pintado Recarte Ana Álvarez Bartolomé Juan Pedro Martínez Cendán Óscar Martínez-Pérez on behalf of the Spanish Obstetric Emergency Group
author_facet	Eva Morán Antolín José Román Broullón Molanes María Luisa de la Cruz Conty María Begoña Encinas Pardilla María del Pilar Guadix Martín José Antonio Sainz Bueno Laura Forcén Acebal Pilar Pintado Recarte Ana Álvarez Bartolomé Juan Pedro Martínez Cendán Óscar Martínez-Pérez on behalf of the Spanish Obstetric Emergency Group
author_sort	Eva Morán Antolín
title	SARS-CoV-2 Infection and C-Section: A Prospective Observational Study
title_short	SARS-CoV-2 Infection and C-Section: A Prospective Observational Study
title_full	SARS-CoV-2 Infection and C-Section: A Prospective Observational Study
title_fullStr	SARS-CoV-2 Infection and C-Section: A Prospective Observational Study
title_full_unstemmed	SARS-CoV-2 Infection and C-Section: A Prospective Observational Study
title_sort	sars-cov-2 infection and c-section: a prospective observational study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6de6369e3e6c4e20b90c8358118fd2b7
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SARS-CoV-2 Infection and C-Section: A Prospective Observational Study

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