Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

mRNA modifications have been shown to regulate mammalian development and disease. Here the authors show that the m6A methyltransferase Mettl3 ensures translational efficiency of the mesenchymal stem cell lineage allocator Pth1r, promoting osteogenesis and protecting from osteoporosis.

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Autores principales:	Yunshu Wu, Liang Xie, Mengyuan Wang, Qiuchan Xiong, Yuchen Guo, Yu Liang, Jing Li, Rui Sheng, Peng Deng, Yuan Wang, Rixin Zheng, Yizhou Jiang, Ling Ye, Qianming Chen, Xuedong Zhou, Shuibin Lin, Quan Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6dee164452b4421384ea332c5f24434f
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spelling	oai:doaj.org-article:6dee164452b4421384ea332c5f24434f2021-12-02T14:39:22ZMettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis10.1038/s41467-018-06898-42041-1723https://doaj.org/article/6dee164452b4421384ea332c5f24434f2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06898-4https://doaj.org/toc/2041-1723mRNA modifications have been shown to regulate mammalian development and disease. Here the authors show that the m6A methyltransferase Mettl3 ensures translational efficiency of the mesenchymal stem cell lineage allocator Pth1r, promoting osteogenesis and protecting from osteoporosis.Yunshu WuLiang XieMengyuan WangQiuchan XiongYuchen GuoYu LiangJing LiRui ShengPeng DengYuan WangRixin ZhengYizhou JiangLing YeQianming ChenXuedong ZhouShuibin LinQuan YuanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunshu Wu Liang Xie Mengyuan Wang Qiuchan Xiong Yuchen Guo Yu Liang Jing Li Rui Sheng Peng Deng Yuan Wang Rixin Zheng Yizhou Jiang Ling Ye Qianming Chen Xuedong Zhou Shuibin Lin Quan Yuan Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
description	mRNA modifications have been shown to regulate mammalian development and disease. Here the authors show that the m6A methyltransferase Mettl3 ensures translational efficiency of the mesenchymal stem cell lineage allocator Pth1r, promoting osteogenesis and protecting from osteoporosis.
format	article
author	Yunshu Wu Liang Xie Mengyuan Wang Qiuchan Xiong Yuchen Guo Yu Liang Jing Li Rui Sheng Peng Deng Yuan Wang Rixin Zheng Yizhou Jiang Ling Ye Qianming Chen Xuedong Zhou Shuibin Lin Quan Yuan
author_facet	Yunshu Wu Liang Xie Mengyuan Wang Qiuchan Xiong Yuchen Guo Yu Liang Jing Li Rui Sheng Peng Deng Yuan Wang Rixin Zheng Yizhou Jiang Ling Ye Qianming Chen Xuedong Zhou Shuibin Lin Quan Yuan
author_sort	Yunshu Wu
title	Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
title_short	Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
title_full	Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
title_fullStr	Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
title_full_unstemmed	Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
title_sort	mettl3-mediated m6a rna methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6dee164452b4421384ea332c5f24434f
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Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

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