TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS

An experimental model of post-traumatic arthritis of knee was developed in a series of 105 white non-inbred rats. Time-dependent changes of some cytokines were studied upon combined treatment with oral nimesulide and intra-articular etoxydole injections. It was found that the knee joint injury we ob...

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Autores principales:	A. N. Zahvatov, S. A. Kozlov, N. A. Atkina, I. I. Dudorov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	post-traumatic arthritis cytokines nimesulidе etoxydol Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6dee95e9821d48bb9752ec7000af8f8f
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spelling	oai:doaj.org-article:6dee95e9821d48bb9752ec7000af8f8f2021-11-18T08:03:45ZTIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS1563-06252313-741X10.15789/1563-0625-2016-1-91-96https://doaj.org/article/6dee95e9821d48bb9752ec7000af8f8f2016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/992https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAn experimental model of post-traumatic arthritis of knee was developed in a series of 105 white non-inbred rats. Time-dependent changes of some cytokines were studied upon combined treatment with oral nimesulide and intra-articular etoxydole injections. It was found that the knee joint injury we observed increased levels of pro- and anti-inflammatory cytokines, which may reflect a development of local immunological response. Combined application of nimesulide and etoxydole contributed to significant reduction in all cytokine pools at the end of observation, bringing their levels to normal ranges typical to the intact animals.A. N. ZahvatovS. A. KozlovN. A. AtkinaI. I. DudorovSPb RAACIarticlepost-traumatic arthritiscytokinesnimesulidеetoxydolImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 1, Pp 91-96 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	post-traumatic arthritis cytokines nimesulidе etoxydol Immunologic diseases. Allergy RC581-607
spellingShingle	post-traumatic arthritis cytokines nimesulidе etoxydol Immunologic diseases. Allergy RC581-607 A. N. Zahvatov S. A. Kozlov N. A. Atkina I. I. Dudorov TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS
description	An experimental model of post-traumatic arthritis of knee was developed in a series of 105 white non-inbred rats. Time-dependent changes of some cytokines were studied upon combined treatment with oral nimesulide and intra-articular etoxydole injections. It was found that the knee joint injury we observed increased levels of pro- and anti-inflammatory cytokines, which may reflect a development of local immunological response. Combined application of nimesulide and etoxydole contributed to significant reduction in all cytokine pools at the end of observation, bringing their levels to normal ranges typical to the intact animals.
format	article
author	A. N. Zahvatov S. A. Kozlov N. A. Atkina I. I. Dudorov
author_facet	A. N. Zahvatov S. A. Kozlov N. A. Atkina I. I. Dudorov
author_sort	A. N. Zahvatov
title	TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS
title_short	TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS
title_full	TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS
title_fullStr	TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS
title_full_unstemmed	TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS
title_sort	time course of cytokine levels in experimental posttraumatic arthritis
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/6dee95e9821d48bb9752ec7000af8f8f
work_keys_str_mv	AT anzahvatov timecourseofcytokinelevelsinexperimentalposttraumaticarthritis AT sakozlov timecourseofcytokinelevelsinexperimentalposttraumaticarthritis AT naatkina timecourseofcytokinelevelsinexperimentalposttraumaticarthritis AT iidudorov timecourseofcytokinelevelsinexperimentalposttraumaticarthritis
_version_	1718422424703205376

TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS

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