In vitro downregulation of matrix metalloproteinase-9 in rat glial cells by CCR5 antagonist maraviroc: therapeutic implication for HIV brain infection.

In vitro downregulation of matrix metalloproteinase-9 in rat glial cells by CCR5 antagonist maraviroc: therapeutic implication for HIV brain infection.

<h4>Background</h4>Matrix metalloproteinases (MMPs) released by glial cells are important mediators of neuroinflammation and neurologic damage in HIV infection. The use of antiretroviral drugs able to combat the detrimental effect of chronic inflammation and target the exaggerated MMP ac...

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Autores principales: Pasqua Gramegna, Tiziana Latronico, Maria Teresa Branà, Gaetano Di Bari, Fabio Mengoni, Valeria Belvisi, Maria T Mascellino, Miriam Lichtner, Vincenzo Vullo, Claudio M Mastroianni, Grazia M Liuzzi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6deeda565a33498bb67337185076b4f1
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