Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

STEAP4 promotes the uptake of copper, and copper is known to be enhanced in cancer tissues. Here, the authors show that STEAP4 is induced by IL17, which is increased in inflamed tissues, consequently the increased copper levels activate NFκB signalling and suppression of apoptosis.

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Autores principales:	Yun Liao, Junjie Zhao, Katarzyna Bulek, Fangqiang Tang, Xing Chen, Gang Cai, Shang Jia, Paul L. Fox, Emina Huang, Theresa T. Pizarro, Matthew F. Kalady, Mark W. Jackson, Shideng Bao, Ganes C. Sen, George R. Stark, Christopher J. Chang, Xiaoxia Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6df31ef881b642eba3b5296a7360af9c
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spelling	oai:doaj.org-article:6df31ef881b642eba3b5296a7360af9c2021-12-02T14:41:14ZInflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis10.1038/s41467-020-14698-y2041-1723https://doaj.org/article/6df31ef881b642eba3b5296a7360af9c2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14698-yhttps://doaj.org/toc/2041-1723STEAP4 promotes the uptake of copper, and copper is known to be enhanced in cancer tissues. Here, the authors show that STEAP4 is induced by IL17, which is increased in inflamed tissues, consequently the increased copper levels activate NFκB signalling and suppression of apoptosis.Yun LiaoJunjie ZhaoKatarzyna BulekFangqiang TangXing ChenGang CaiShang JiaPaul L. FoxEmina HuangTheresa T. PizarroMatthew F. KaladyMark W. JacksonShideng BaoGanes C. SenGeorge R. StarkChristopher J. ChangXiaoxia LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yun Liao Junjie Zhao Katarzyna Bulek Fangqiang Tang Xing Chen Gang Cai Shang Jia Paul L. Fox Emina Huang Theresa T. Pizarro Matthew F. Kalady Mark W. Jackson Shideng Bao Ganes C. Sen George R. Stark Christopher J. Chang Xiaoxia Li Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
description	STEAP4 promotes the uptake of copper, and copper is known to be enhanced in cancer tissues. Here, the authors show that STEAP4 is induced by IL17, which is increased in inflamed tissues, consequently the increased copper levels activate NFκB signalling and suppression of apoptosis.
format	article
author	Yun Liao Junjie Zhao Katarzyna Bulek Fangqiang Tang Xing Chen Gang Cai Shang Jia Paul L. Fox Emina Huang Theresa T. Pizarro Matthew F. Kalady Mark W. Jackson Shideng Bao Ganes C. Sen George R. Stark Christopher J. Chang Xiaoxia Li
author_facet	Yun Liao Junjie Zhao Katarzyna Bulek Fangqiang Tang Xing Chen Gang Cai Shang Jia Paul L. Fox Emina Huang Theresa T. Pizarro Matthew F. Kalady Mark W. Jackson Shideng Bao Ganes C. Sen George R. Stark Christopher J. Chang Xiaoxia Li
author_sort	Yun Liao
title	Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
title_short	Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
title_full	Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
title_fullStr	Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
title_full_unstemmed	Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
title_sort	inflammation mobilizes copper metabolism to promote colon tumorigenesis via an il-17-steap4-xiap axis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6df31ef881b642eba3b5296a7360af9c
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Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

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