Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation

During mammary gland involution, the organ undergoes extensive remodeling. Here, the authors explore the role of mammary gland adipose tissue (mgWAT) in this process and demonstrate that adipocyte hypertrophy and lipid trafficking underlie mgWAT expansion and epithelial regression.

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Auteurs principaux:	Rachel K. Zwick, Michael C. Rudolph, Brett A. Shook, Brandon Holtrup, Eve Roth, Vivian Lei, Alexandra Van Keymeulen, Victoria Seewaldt, Stephanie Kwei, John Wysolmerski, Matthew S. Rodeheffer, Valerie Horsley
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/6df449e761d24bb9b6a16a56627b5f82
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spelling	oai:doaj.org-article:6df449e761d24bb9b6a16a56627b5f822021-12-02T14:40:55ZAdipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation10.1038/s41467-018-05911-02041-1723https://doaj.org/article/6df449e761d24bb9b6a16a56627b5f822018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05911-0https://doaj.org/toc/2041-1723During mammary gland involution, the organ undergoes extensive remodeling. Here, the authors explore the role of mammary gland adipose tissue (mgWAT) in this process and demonstrate that adipocyte hypertrophy and lipid trafficking underlie mgWAT expansion and epithelial regression.Rachel K. ZwickMichael C. RudolphBrett A. ShookBrandon HoltrupEve RothVivian LeiAlexandra Van KeymeulenVictoria SeewaldtStephanie KweiJohn WysolmerskiMatthew S. RodehefferValerie HorsleyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rachel K. Zwick Michael C. Rudolph Brett A. Shook Brandon Holtrup Eve Roth Vivian Lei Alexandra Van Keymeulen Victoria Seewaldt Stephanie Kwei John Wysolmerski Matthew S. Rodeheffer Valerie Horsley Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
description	During mammary gland involution, the organ undergoes extensive remodeling. Here, the authors explore the role of mammary gland adipose tissue (mgWAT) in this process and demonstrate that adipocyte hypertrophy and lipid trafficking underlie mgWAT expansion and epithelial regression.
format	article
author	Rachel K. Zwick Michael C. Rudolph Brett A. Shook Brandon Holtrup Eve Roth Vivian Lei Alexandra Van Keymeulen Victoria Seewaldt Stephanie Kwei John Wysolmerski Matthew S. Rodeheffer Valerie Horsley
author_facet	Rachel K. Zwick Michael C. Rudolph Brett A. Shook Brandon Holtrup Eve Roth Vivian Lei Alexandra Van Keymeulen Victoria Seewaldt Stephanie Kwei John Wysolmerski Matthew S. Rodeheffer Valerie Horsley
author_sort	Rachel K. Zwick
title	Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
title_short	Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
title_full	Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
title_fullStr	Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
title_full_unstemmed	Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
title_sort	adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6df449e761d24bb9b6a16a56627b5f82
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Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation

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