Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts

Abstract This study aimed to analyze the clinical features of anti-SAE antibodies in Chinese myositis patients in comparison with different cohorts. The anti-SAE antibodies were tested in myositis patients and in control subjects. Long-term follow-up was conducted on the antibody-positive patients....

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Autores principales:	Yongpeng Ge, Xin Lu, Xiaoming Shu, Qinglin Peng, Guochun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6df474890d9147e499c15c44818ebc67
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spelling	oai:doaj.org-article:6df474890d9147e499c15c44818ebc672021-12-02T12:32:40ZClinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts10.1038/s41598-017-00240-62045-2322https://doaj.org/article/6df474890d9147e499c15c44818ebc672017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00240-6https://doaj.org/toc/2045-2322Abstract This study aimed to analyze the clinical features of anti-SAE antibodies in Chinese myositis patients in comparison with different cohorts. The anti-SAE antibodies were tested in myositis patients and in control subjects. Long-term follow-up was conducted on the antibody-positive patients. Anti-SAE antibodies were exclusively present in 12 out of 394 (3.0%) adult dermatomyositis (DM) patients. Of the anti-SAE-positive DM patients, 75% had distinctive diffuse dark-red or pigment-like skin rashes, and 67% of these patients experienced mild muscle weakness. Muscular biopsies showed mild pathological manifestations. Compared with the antibody-negative group, the average age of dermatomyositis onset in the antibody-positive group was higher, and dysphagia occurred more frequently noted (p = 0.012). Only 9 patients received follow-up, 7 experienced improvement after treatment. The anti-SAE antibody levels correlated with improved disease condition. The anti-SAE antibody was found exclusively in adult DM patients, occurring infrequently in Chinese patients. In addition to a diffuse dark-red or pigment-like skin rash and mild muscular weakness, common symptoms included propensity for developing dysphagia. Serum levels of the anti-SAE antibody correlated with myositis disease activity, and anti-SAE-positive patients were responsive to treatment.Yongpeng GeXin LuXiaoming ShuQinglin PengGuochun WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yongpeng Ge Xin Lu Xiaoming Shu Qinglin Peng Guochun Wang Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts
description	Abstract This study aimed to analyze the clinical features of anti-SAE antibodies in Chinese myositis patients in comparison with different cohorts. The anti-SAE antibodies were tested in myositis patients and in control subjects. Long-term follow-up was conducted on the antibody-positive patients. Anti-SAE antibodies were exclusively present in 12 out of 394 (3.0%) adult dermatomyositis (DM) patients. Of the anti-SAE-positive DM patients, 75% had distinctive diffuse dark-red or pigment-like skin rashes, and 67% of these patients experienced mild muscle weakness. Muscular biopsies showed mild pathological manifestations. Compared with the antibody-negative group, the average age of dermatomyositis onset in the antibody-positive group was higher, and dysphagia occurred more frequently noted (p = 0.012). Only 9 patients received follow-up, 7 experienced improvement after treatment. The anti-SAE antibody levels correlated with improved disease condition. The anti-SAE antibody was found exclusively in adult DM patients, occurring infrequently in Chinese patients. In addition to a diffuse dark-red or pigment-like skin rash and mild muscular weakness, common symptoms included propensity for developing dysphagia. Serum levels of the anti-SAE antibody correlated with myositis disease activity, and anti-SAE-positive patients were responsive to treatment.
format	article
author	Yongpeng Ge Xin Lu Xiaoming Shu Qinglin Peng Guochun Wang
author_facet	Yongpeng Ge Xin Lu Xiaoming Shu Qinglin Peng Guochun Wang
author_sort	Yongpeng Ge
title	Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts
title_short	Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts
title_full	Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts
title_fullStr	Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts
title_full_unstemmed	Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts
title_sort	clinical characteristics of anti-sae antibodies in chinese patients with dermatomyositis in comparison with different patient cohorts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6df474890d9147e499c15c44818ebc67
work_keys_str_mv	AT yongpengge clinicalcharacteristicsofantisaeantibodiesinchinesepatientswithdermatomyositisincomparisonwithdifferentpatientcohorts AT xinlu clinicalcharacteristicsofantisaeantibodiesinchinesepatientswithdermatomyositisincomparisonwithdifferentpatientcohorts AT xiaomingshu clinicalcharacteristicsofantisaeantibodiesinchinesepatientswithdermatomyositisincomparisonwithdifferentpatientcohorts AT qinglinpeng clinicalcharacteristicsofantisaeantibodiesinchinesepatientswithdermatomyositisincomparisonwithdifferentpatientcohorts AT guochunwang clinicalcharacteristicsofantisaeantibodiesinchinesepatientswithdermatomyositisincomparisonwithdifferentpatientcohorts
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Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts

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